Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Kytril was a granisetron hydrochloride trade name used for oral and injectable antiemetic products. FDA lists the original Kytril products as discontinued, while generic granisetron tablets and injections remain marketed in the United States.
read more about what was kytril ...Granisetron selectively blocks serotonin 5-HT3 receptors involved in nausea and vomiting pathways. This action reduces emetic signaling associated with cancer therapy and other labeled settings.
Historical oral Kytril labeling included prevention of nausea and vomiting associated with emetogenic cancer therapy and with radiation, including total body irradiation and fractionated abdominal radiation. Current generic oral granisetron tablets retain these uses.
For emetogenic chemotherapy, adults received 2 mg once up to one hour before treatment or 1 mg up to one hour before treatment followed by another 1 mg 12 hours later. For radiation, adults received 2 mg within one hour before radiation. Current generic oral granisetron labeling uses the same dose schedules.
Serious concerns include serotonin syndrome, particularly with other serotonergic medicines, and QT prolongation in patients with heart rhythm disorders or other risk factors. Granisetron can also mask progressive ileus or gastric distention after abdominal surgery or during chemotherapy-related nausea and vomiting.
Kytril contained granisetron hydrochloride, a serotonin 5-HT3 receptor antagonist.
No. FDA lists the original Kytril products as discontinued.
Yes. Generic granisetron tablets remain marketed in the United States.
The labeled adult dose is 2 mg taken within one hour before radiation.
DailyMed - GRANISETRON HYDROCHLORIDE tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=50b713d3-7ca8-465a-aefa-65ddbe17b934. Date Accessed October 8, 2026.
Determination That KYTRIL (Granisetron Hydrochloride) Tablets Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness. Federal Register. https://www.govinfo.gov/content/pkg/FR-2015-12-28/pdf/2015-32496.pdf. Date Accessed October 8, 2026.
Granisetron. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a601211.html. Date Accessed October 8, 2026.
Granisetron Hydrochloride. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/granisetronhydrochloride. Date Accessed October 8, 2026.
Granisetron Hydrochloride. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Granisetron-Hydrochloride. Date Accessed October 8, 2026.