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A diagnostic sign observed during a slit lamp or ophthalmoscopic exam where light shone through the pupil or across the iris reveals an area where the iris pigment epithelium is missing, allowing light to pass through.
read more about transillumination defect ...The defect appears as a small, bright spot of light shining back through the iris, contrasting with the surrounding dark, opaque tissue. This occurs due to tissue atrophy or pigment loss.
Commonly associated with certain types of glaucoma (Pigmentary Glaucoma), herpes zoster ophthalmicus, trauma, or iris atrophy (loss of tissue), often caused by chronic inflammation.
Best observed by aiming a narrow slit lamp beam across the anterior chamber and looking for light reflecting from the fundus back through the iris defect.
A defect implies a thin, translucent area with missing pigment. An iris hole (iridotomy) is a surgically created or accidental full-thickness aperture.
No, but severe defects, particularly a spoke-wheel pattern, are highly characteristic of Pigment Dispersion Syndrome, which can lead to Pigmentary Glaucoma.
Small defects are only visible via transillumination. Larger, full-thickness holes may be visible directly.