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Topical hydrocortisone is a corticosteroid medicine used on the skin. Prescription hydrocortisone cream 2.5 percent contains 25 mg of hydrocortisone per gram. It is indicated for inflammatory and itchy skin conditions that respond to corticosteroids.
read more about topical hydrocortisone ...Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive actions. The precise anti-inflammatory mechanism is not fully defined. Hydrocortisone reduces local inflammatory activity in corticosteroid-responsive skin disorders.
Prescription hydrocortisone cream 2.5 percent is used for inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Selection depends on the skin disorder, treatment area, severity, and response. Children can absorb proportionally larger amounts through the skin and have greater susceptibility to systemic corticosteroid effects.
A thin film of hydrocortisone cream 2.5 percent is applied to the affected area two to four times daily depending on severity. Occlusive dressings are used only when directed for selected resistant skin conditions. Treatment stops if significant irritation develops.
Topical corticosteroids can be absorbed through the skin and suppress the hypothalamic-pituitary-adrenal axis, especially with large treatment areas, prolonged use, or occlusive dressings. Other local reactions include burning, irritation, dryness, folliculitis, acne-like eruptions, skin thinning, striae, and secondary infection. Hypersensitivity to a product component is a contraindication.
It treats inflammatory and itchy skin conditions that respond to topical corticosteroids.
Current prescription labeling directs application of a thin film two to four times daily depending on severity.
Yes. Absorption through the skin can suppress adrenal function, especially with extensive or prolonged treatment.
Yes. Children can absorb proportionally larger amounts and have greater susceptibility to systemic corticosteroid toxicity.
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Hydrocortisone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydrocortisone. Date Accessed October 1, 2026.
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Hydrocortisone Topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682793.html. Date Accessed October 1, 2026.
Topical Corticosteroids. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK532940/. Date Accessed October 1, 2026.