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What Is Repatha?

Repatha is a prescription injectable cholesterol-lowering medication containing evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, or PCSK9. It is used to lower low-density lipoprotein cholesterol, commonly called LDL cholesterol, in eligible adults and children with certain inherited cholesterol disorders. Repatha is also approved to reduce the risk of major cardiovascular events in adults at increased risk. It is administered beneath the skin every two weeks or monthly, depending on the prescribed regimen. Repatha works differently from statins and may be used alongside other cholesterol-lowering treatments when appropriate.

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What Is Repatha?

Repatha is a prescription injectable cholesterol-lowering medication containing evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, or PCSK9. It is used to lower low-density lipoprotein cholesterol, commonly called LDL cholesterol, in eligible adults and children with certain inherited cholesterol disorders. Repatha is also approved to reduce the risk of major cardiovascular events in adults at increased risk. It is administered beneath the skin every two weeks or monthly, depending on the prescribed regimen. Repatha works differently from statins and may be used alongside other cholesterol-lowering treatments when appropriate.

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How Does Repatha Work?

Repatha binds to PCSK9, a protein that contributes to the breakdown of LDL receptors on liver cells. LDL receptors remove LDL cholesterol from the bloodstream. By inhibiting PCSK9, evolocumab allows more LDL receptors to remain available, increasing the liver's ability to clear circulating LDL cholesterol. This can substantially reduce LDL levels and lower the risk of certain cardiovascular events in eligible adults. Repatha does not directly block cholesterol synthesis like statins. Its effect is monitored through cholesterol measurements and an assessment of the patient's cardiovascular risk and treatment response.

What Conditions Does Repatha Treat?

Repatha is approved to reduce major cardiovascular events, including cardiovascular death, heart attack, stroke, hospitalization for unstable angina, and certain procedures to restore arterial blood flow, in adults at increased risk. It is also approved alongside diet and exercise to lower LDL cholesterol in adults with hypercholesterolemia. Adults and children aged 10 years and older with heterozygous or homozygous familial hypercholesterolemia may also receive Repatha. These inherited conditions cause elevated LDL cholesterol due to genetic factors. A clinician evaluates cholesterol levels, cardiovascular history, previous treatments, and the patient's overall risk before prescribing it.

How Is Repatha Administered?

Repatha is administered by subcutaneous injection into the abdomen, thigh, or upper arm. For most adults receiving treatment for elevated LDL cholesterol or cardiovascular risk reduction, the recommended dose is either 140 mg every two weeks or 420 mg once monthly. The same options apply to patients aged 10 years and older with heterozygous familial hypercholesterolemia. For homozygous familial hypercholesterolemia, treatment generally begins at 420 mg monthly and may increase to 420 mg every two weeks if the response is inadequate after 12 weeks. Patients or caregivers should receive injection training, rotate injection sites, and follow the product-specific storage instructions.

What Are the Side Effects and Warnings of Repatha?

Common adverse effects include injection-site reactions, upper respiratory symptoms, nasopharyngitis, back pain, and flu-like symptoms. Some patients experience redness, pain, bruising, or swelling where the medication is injected. Serious hypersensitivity reactions, including angioedema, can occur. Repatha is contraindicated in patients with a history of serious hypersensitivity to evolocumab or any product component. Certain syringe and autoinjector presentations may contain dry natural rubber derived from latex in the needle cover, so patients with latex sensitivity should review the specific device. Difficulty breathing, facial swelling, or a severe allergic reaction requires immediate medical attention.

Common Questions About Repatha

Is Repatha the same as evolocumab?

Yes. Repatha is the brand name for evolocumab, an injectable PCSK9 inhibitor used to lower LDL cholesterol and reduce certain cardiovascular risks.

Is Repatha a statin?

No. Repatha is a monoclonal antibody that blocks PCSK9. Statins lower cholesterol through a different mechanism.

How often is Repatha injected?

Many patients receive 140 mg every two weeks or 420 mg monthly. Patients with homozygous familial hypercholesterolemia may require a different schedule.

Can children receive Repatha?

Yes. Repatha is approved for children aged 10 years and older with heterozygous or homozygous familial hypercholesterolemia.

References

DailyMed - REPATHA (evolocumab) injection, solution. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd61e902-166d-4aa6-9f3c-a18c1008d07e. Date Accessed November 3, 2026.

Evolocumab. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548469/. Date Accessed November 3, 2026.

Evolocumab. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Evolocumab. Date Accessed November 3, 2026.

Evolocumab Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a615043.html. Date Accessed November 3, 2026.

Repatha. European Medicines Agency. https://www.ema.europa.eu/en/medicines/human/EPAR/repatha. Date Accessed November 3, 2026.