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What Is Opcon-A?

Opcon-A is an over-the-counter ophthalmic medication used for temporary relief of eye itching and redness caused by allergies. It contains pheniramine maleate 0.315%, an antihistamine, and naphazoline hydrochloride 0.02675%, an eye redness reliever. The combination is intended for allergy symptoms triggered by pollen, grass, ragweed, and animal dander. Opcon-A does not treat bacterial eye infections or correct vision. Contact lenses must be removed before using the drops.

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What Is Opcon-A?

Opcon-A is an over-the-counter ophthalmic medication used for temporary relief of eye itching and redness caused by allergies. It contains pheniramine maleate 0.315%, an antihistamine, and naphazoline hydrochloride 0.02675%, an eye redness reliever. The combination is intended for allergy symptoms triggered by pollen, grass, ragweed, and animal dander. Opcon-A does not treat bacterial eye infections or correct vision. Contact lenses must be removed before using the drops.

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How Does Opcon-A Work?

Opcon-A combines two active ingredients with different actions. Pheniramine blocks histamine H1 receptors, helping reduce itching associated with allergic reactions. Naphazoline stimulates alpha-adrenergic receptors in blood vessels on the eye's surface, causing temporary narrowing that reduces visible redness. Together, these effects relieve certain allergy-related symptoms. Opcon-A does not eliminate the underlying allergy. Excessive use of redness-relieving drops can cause increased eye redness and irritation.

What Eye Symptoms Does Opcon-A Treat?

Opcon-A temporarily relieves itching and redness caused by allergens such as pollen, ragweed, grass, animal hair, and dander. Allergic eye reactions can cause itchy, watery, and visibly red eyes, particularly after exposure to environmental triggers. Opcon-A is not intended for infections, corneal injuries, or discomfort caused directly by contact lenses. Eye pain, changes in vision, or redness lasting longer than 72 hours require medical evaluation. Patients with narrow-angle glaucoma or certain cardiovascular conditions should consult a doctor before use.

How Should Opcon-A Eye Drops Be Used?

Adults and children aged six years and older can instill one or two drops into the affected eye or eyes up to four times daily. Children younger than six years should use the product only after consulting a doctor. Wash hands before application and avoid touching the bottle tip to the eye or other surfaces. Remove contact lenses before applying Opcon-A. Do not use the solution when it becomes cloudy or changes color. Follow the package directions and avoid exceeding the recommended frequency.

What Are the Side Effects and Warnings of Opcon-A?

Opcon-A can cause temporary tingling, stinging, or irritation after application. Naphazoline can temporarily enlarge the pupils, and excessive use can worsen eye redness. People with heart disease, high blood pressure, urinary problems associated with an enlarged prostate, or narrow-angle glaucoma should seek medical advice before using it. Stop treatment and contact a doctor when eye pain, vision changes, or worsening redness occurs. Accidental swallowing, particularly by young children, can cause serious poisoning and requires immediate medical attention.

Common Questions About Opcon-A

Is Opcon-A an antihistamine eye drop?

Yes. Opcon-A contains pheniramine, an antihistamine, together with naphazoline, a medication that temporarily reduces visible eye redness.

Can Opcon-A be used with contact lenses?

Contact lenses must be removed before using Opcon-A. Patients should follow professional guidance about when to resume lens wear and should avoid wearing lenses while their eyes remain irritated.

How often can Opcon-A be used?

Adults and children aged six years and older can use one or two drops in each affected eye up to four times daily according to the product label.

Can Opcon-A cause rebound redness?

Yes. Excessive use of naphazoline-containing eye drops can result in increased redness. Persistent symptoms should be evaluated by an eye care professional.

References

DailyMed - OPCON-A (naphazoline hydrochloride and pheniramine maleate) ophthalmic solution. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d7cfae7-8af4-4fee-93e1-e5cfe455c5a5. Date Accessed October 22, 2026.

Naphazoline. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/4436. Date Accessed October 22, 2026.

Naphazoline; Pheniramine Eye Solution. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19674-naphazoline-pheniramine-eye-solution. Date Accessed October 22, 2026.

Opcon-A Antihistamine and Redness Reliever Eye Drops. Bausch + Lomb. https://www.bausch.com/products/otc-eye-care-supplements/allergy-relief/. Date Accessed October 22, 2026.

Pheniramine Maleate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Pheniramine-Maleate. Date Accessed October 22, 2026.