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What Is Onfi?

Onfi is a prescription medication containing clobazam, a benzodiazepine anticonvulsant. It is approved as an additional treatment for seizures associated with Lennox-Gastaut syndrome in patients aged two years and older. Lennox-Gastaut syndrome is a severe form of epilepsy involving multiple seizure types and developmental or cognitive difficulties. Onfi is available as oral tablets and an oral suspension. It is a Schedule IV controlled substance because it carries risks of misuse, dependence, and withdrawal.

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What Is Onfi?

Onfi is a prescription medication containing clobazam, a benzodiazepine anticonvulsant. It is approved as an additional treatment for seizures associated with Lennox-Gastaut syndrome in patients aged two years and older. Lennox-Gastaut syndrome is a severe form of epilepsy involving multiple seizure types and developmental or cognitive difficulties. Onfi is available as oral tablets and an oral suspension. It is a Schedule IV controlled substance because it carries risks of misuse, dependence, and withdrawal.

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How Does Onfi Work?

Onfi contains clobazam, which increases the effects of gamma-aminobutyric acid, or GABA, at GABA-A receptors in the brain. GABA is an inhibitory neurotransmitter that reduces excessive electrical signaling between nerve cells. By strengthening its activity, clobazam helps reduce seizures associated with Lennox-Gastaut syndrome. It is used alongside other antiseizure treatments rather than as a cure for epilepsy. Its effects and tolerability depend on the dose, other medications, and patient characteristics.

Who Can Receive Onfi Treatment?

Onfi is approved for patients aged two years and older who experience seizures associated with Lennox-Gastaut syndrome. It is prescribed as adjunctive therapy, meaning patients generally continue other antiseizure medications. A neurologist considers seizure types, body weight, liver function, other medicines, and the risk of sedation before treatment. Onfi is not approved specifically for every type of epilepsy or as routine treatment for anxiety. Treatment requires monitoring for behavioral changes, severe skin reactions, and excessive sedation.

How Should Onfi Be Taken?

Onfi is taken orally as tablets or suspension, with dosing based on body weight and individual response. Patients weighing 30 kilograms or less generally begin at 5 mg daily, while those weighing more than 30 kilograms generally begin at 10 mg daily. Doses are increased gradually, generally no faster than weekly. Daily amounts greater than 5 mg should be divided into two doses. Tablets can be taken with or without food. Onfi must not be stopped abruptly because serious withdrawal symptoms and increased seizures can occur.

What Are the Side Effects and Warnings of Onfi?

Common adverse effects include sleepiness, sedation, fatigue, drooling, constipation, and behavioral changes. Onfi carries boxed warnings for life-threatening breathing suppression when combined with opioids, abuse and addiction, and physical dependence with withdrawal reactions. Serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, can also occur. Antiseizure medications carry warnings about suicidal thoughts or behavior. Patients should avoid alcohol and discuss other sedating medications with the prescribing clinician.

Common Questions About Onfi

Is Onfi the same as clobazam?

Yes. Onfi is a brand name for clobazam, a benzodiazepine anticonvulsant used as adjunctive treatment for Lennox-Gastaut syndrome.

Can Onfi treat Lennox-Gastaut syndrome?

Yes. Onfi is approved to reduce seizures associated with Lennox-Gastaut syndrome in patients aged two years and older.

Is Onfi a controlled substance?

Yes. Onfi contains clobazam, a Schedule IV controlled substance associated with risks of misuse, dependence, and withdrawal.

Can Onfi be stopped suddenly?

No. Abruptly stopping Onfi can cause serious withdrawal reactions and increased seizure activity. A healthcare professional should supervise gradual dose reduction.

References

Clobazam. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548865/. Date Accessed October 22, 2026.

Clobazam. MedlinePlus. https://medlineplus.gov/druginfo/meds/a612008.html. Date Accessed October 22, 2026.

Clobazam. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Clobazam. Date Accessed October 22, 2026.

Clobazam. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK541043/. Date Accessed October 22, 2026.

DailyMed - ONFI (clobazam) tablets and oral suspension. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de03bd69-2dca-459c-93b4-541fd3e9571c. Date Accessed October 22, 2026.