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What Is Nurtec ODT?

Nurtec ODT is a prescription medication containing rimegepant, a calcitonin gene-related peptide (CGRP) receptor antagonist. It is approved for the acute treatment of migraine with or without aura in adults and for the preventive treatment of episodic migraine in adults. Nurtec ODT comes as a 75 mg orally disintegrating tablet that dissolves on or under the tongue. It can be used to treat an individual migraine attack or taken on a scheduled basis to reduce migraine frequency.

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What Is Nurtec ODT?

Nurtec ODT is a prescription medication containing rimegepant, a calcitonin gene-related peptide (CGRP) receptor antagonist. It is approved for the acute treatment of migraine with or without aura in adults and for the preventive treatment of episodic migraine in adults. Nurtec ODT comes as a 75 mg orally disintegrating tablet that dissolves on or under the tongue. It can be used to treat an individual migraine attack or taken on a scheduled basis to reduce migraine frequency.

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How Does Nurtec ODT Work?

Nurtec ODT blocks receptors for calcitonin gene-related peptide, a signaling molecule involved in migraine-related pain pathways. CGRP contributes to pain transmission and other processes associated with migraine attacks. By preventing CGRP from activating its receptors, rimegepant helps reduce migraine symptoms and can decrease migraine frequency when taken preventively. Unlike triptans, Nurtec ODT does not work by directly constricting blood vessels. It does not cure migraine or eliminate every future attack.

What Types of Migraines Does Nurtec ODT Treat?

Nurtec ODT is approved to treat migraine attacks with or without aura in adults. It is also used to prevent episodic migraine, a condition involving recurring migraine attacks separated by periods without migraine symptoms. Acute treatment is taken when an attack occurs, while preventive treatment follows an every-other-day schedule. Nurtec ODT is not approved for cluster headaches or for migraine treatment in children. A healthcare professional considers attack frequency, other medications, and medical history before prescribing it.

How Should Nurtec ODT Be Taken?

For acute migraine treatment, the recommended dose is 75 mg taken as needed. For preventive treatment of episodic migraine, the recommended dose is 75 mg every other day. The maximum dose is 75 mg within 24 hours, and the safety of taking more than 18 doses in a 30-day period has not been established. Remove the tablet from its blister with dry hands and place it on or under the tongue to dissolve. Water is not required, and the medication can be taken with or without food.

What Are the Side Effects and Warnings of Nurtec ODT?

Common adverse effects include nausea and, during preventive treatment, abdominal pain or indigestion. Serious allergic reactions can occur, including rash, difficulty breathing, and delayed hypersensitivity reactions. Nurtec ODT can also cause new or worsening high blood pressure and Raynaud's phenomenon. Certain medications can increase or decrease rimegepant exposure, requiring dose restrictions or avoidance of specific combinations. Patients with severe liver impairment or end-stage kidney disease should not use Nurtec ODT according to prescribing recommendations.

Common Questions About Nurtec ODT

Can Nurtec ODT treat a migraine after it starts?

Yes. Nurtec ODT is approved for the acute treatment of migraine with or without aura in adults. The recommended dose is 75 mg when needed.

Can Nurtec ODT prevent migraines?

Yes. Nurtec ODT is approved to prevent episodic migraine in adults. The recommended preventive schedule is one 75 mg tablet every other day.

Can Nurtec ODT be taken every day?

The maximum recommended dose is 75 mg within 24 hours, but scheduled preventive treatment is every other day. The safety of more than 18 doses in 30 days has not been established.

Does Nurtec ODT cause drowsiness?

Drowsiness is not among its most commonly reported adverse effects. Nausea and abdominal discomfort are more commonly reported, although individual reactions can differ.

References

DailyMed - NURTEC ODT (rimegepant sulfate) orally disintegrating tablet. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9ef08e09-1098-35cc-e053-2a95a90a3e1d. Date Accessed October 22, 2026.

Rimegepant. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK572432/. Date Accessed October 22, 2026.

Rimegepant. MedlinePlus. https://medlineplus.gov/druginfo/meds/a620031.html. Date Accessed October 22, 2026.

Rimegepant. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Rimegepant. Date Accessed October 22, 2026.

Rimegepant: A Review in the Acute Treatment and Preventive Treatment of Migraine. CNS Drugs. https://pubmed.ncbi.nlm.nih.gov/36739335/. Date Accessed October 22, 2026.