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What Is Nitrostat?

Nitrostat is a prescription medication containing nitroglycerin, a nitrate vasodilator used to relieve or prevent angina caused by coronary artery disease. Angina occurs when the heart muscle does not receive enough oxygen-rich blood, producing chest discomfort or pressure. Nitrostat comes as sublingual tablets that dissolve under the tongue or inside the cheek. It works rapidly during an angina episode and can also be taken before activities known to trigger chest pain.

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What Is Nitrostat?

Nitrostat is a prescription medication containing nitroglycerin, a nitrate vasodilator used to relieve or prevent angina caused by coronary artery disease. Angina occurs when the heart muscle does not receive enough oxygen-rich blood, producing chest discomfort or pressure. Nitrostat comes as sublingual tablets that dissolve under the tongue or inside the cheek. It works rapidly during an angina episode and can also be taken before activities known to trigger chest pain.

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How Does Nitrostat Work?

Nitrostat relaxes blood vessels by increasing nitric oxide signaling in vascular smooth muscle. This reduces the amount of blood returning to the heart and lowers the heart's workload and oxygen requirements. Nitroglycerin also relaxes coronary arteries, which can improve blood flow in certain circumstances. These actions help relieve chest discomfort associated with angina. Nitrostat treats angina symptoms but does not eliminate coronary artery disease or prevent every cardiovascular emergency.

What Conditions Does Nitrostat Treat?

Nitrostat is approved for acute relief of angina pectoris caused by coronary artery disease and for short-term prevention before activities that commonly trigger angina. These activities can include physical exertion or other situations that increase cardiac oxygen demand. Nitrostat is not intended as a daily long-acting replacement for preventive cardiovascular medications. New, severe, or unusual chest discomfort requires urgent medical evaluation because it can indicate a heart attack or another serious condition.

How Should Nitrostat Be Taken?

At the first sign of an angina attack, place one prescribed Nitrostat tablet beneath the tongue or inside the cheek and allow it to dissolve without swallowing. Sit down while taking it because dizziness or low blood pressure can occur. Another tablet can be used every five minutes when needed, up to three tablets within 15 minutes. Seek emergency medical assistance immediately for severe, unusual, or persistent chest pain according to the prescribed emergency action plan. For prevention, Nitrostat can be taken five to ten minutes before a triggering activity.

What Are the Side Effects and Warnings of Nitrostat?

Common side effects include headache, dizziness, flushing, and tingling sensations. Nitrostat can cause a significant drop in blood pressure, leading to weakness or fainting. It must not be combined with erectile dysfunction medications such as sildenafil, tadalafil, or vardenafil, or with soluble guanylate cyclase stimulators, because dangerous hypotension can result. Nitrostat is also contraindicated in severe anemia, shock, and increased intracranial pressure. Patients should discuss all cardiovascular medications with their prescriber.

Common Questions About Nitrostat

Is Nitrostat the same as nitroglycerin?

Yes. Nitrostat is a brand name for nitroglycerin sublingual tablets. Other nitroglycerin formulations have different administration instructions and intended uses.

How quickly does Nitrostat work?

Nitrostat generally begins relieving angina within a few minutes after dissolving under the tongue. Persistent or unusual chest pain requires emergency medical evaluation.

Can Nitrostat be taken before exercise?

Yes. Nitrostat can be taken five to ten minutes before activities known to trigger angina when directed by a healthcare professional.

Can Nitrostat be taken with Viagra?

No. Nitrostat must not be combined with Viagra, which contains sildenafil, or other PDE-5 inhibitors because the combination can cause a dangerous drop in blood pressure.

References

DailyMed - NITROSTAT (nitroglycerin) sublingual tablet. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5265648f-3062-48a2-a4e3-fea1207807a8. Date Accessed October 19, 2026.

Nitroglycerin. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/4510. Date Accessed October 19, 2026.

Nitroglycerin. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK482382/. Date Accessed October 19, 2026.

Nitroglycerin Sublingual. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601086.html. Date Accessed October 19, 2026.

Nitroglycerin Sublingual Tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/20423-nitroglycerin-sublingual-tablets. Date Accessed October 19, 2026.