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What Is Neffy?

Neffy is a prescription epinephrine nasal spray used for emergency treatment of severe type I allergic reactions, including anaphylaxis. It is approved for adults and children weighing at least 15 kilograms (33 pounds). Neffy delivers epinephrine through the nose without an injection. It is intended for emergency use when a serious allergic reaction occurs, including reactions to foods, medications, or insect stings.

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What Is Neffy?

Neffy is a prescription epinephrine nasal spray used for emergency treatment of severe type I allergic reactions, including anaphylaxis. It is approved for adults and children weighing at least 15 kilograms (33 pounds). Neffy delivers epinephrine through the nose without an injection. It is intended for emergency use when a serious allergic reaction occurs, including reactions to foods, medications, or insect stings.

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How Does Neffy Work?

Neffy contains epinephrine, a medication that activates alpha- and beta-adrenergic receptors. It helps constrict blood vessels, raise dangerously low blood pressure, relax airway muscles, and reduce swelling during anaphylaxis. These effects counter several life-threatening symptoms of severe allergic reactions. Neffy acts through nasal absorption rather than injection, making it an alternative to epinephrine auto-injectors for eligible patients.

When Should Neffy Be Used?

Neffy is used when anaphylaxis or another severe type I allergic reaction is suspected. Symptoms can include difficulty breathing, throat swelling, wheezing, faintness, widespread hives, or a sudden drop in blood pressure. Anaphylaxis can develop rapidly and requires immediate treatment. Administer epinephrine promptly according to the prescribed emergency action plan and follow medical instructions for obtaining emergency assistance and further evaluation.

How Is Neffy Administered?

Neffy is administered as a single spray into one nostril. Patients weighing 15 kilograms to less than 30 kilograms receive the 1 mg product, while those weighing at least 30 kilograms receive the 2 mg product. A second dose can be given in the same nostril using a new device starting five minutes after the first dose when symptoms do not improve or worsen. Follow the prescribed emergency action plan and product instructions.

What Are the Side Effects and Precautions of Neffy?

Possible side effects include headache, nasal discomfort, throat irritation, nausea, trembling, and increased heart rate. Epinephrine can also cause temporary increases in blood pressure and feelings of anxiety. Patients with certain cardiovascular conditions require particular caution, although there are no absolute contraindications to Neffy during anaphylaxis. Severe allergic reactions can recur or require further treatment, so follow the prescribed instructions for emergency medical evaluation.

Common Questions About Neffy

Is Neffy the same as an EpiPen?

Neffy and EpiPen both contain epinephrine and are used to treat anaphylaxis. Neffy is administered as a nasal spray, while EpiPen delivers epinephrine through an intramuscular injection.

Can children use Neffy?

Yes. Neffy is approved for children weighing at least 15 kilograms (33 pounds). The prescribed strength depends on the child's body weight.

How quickly should Neffy be used during an allergic reaction?

Neffy should be administered immediately when anaphylaxis is suspected. Delaying epinephrine treatment can allow symptoms to become life-threatening.

Can Neffy be administered more than once?

Yes. A second dose can be administered using a new device starting five minutes after the first dose when symptoms persist or worsen. Follow the prescribed emergency action plan.

References

DailyMed - NEFFY (epinephrine) nasal spray. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a1758142-a905-401d-8961-05829f51023a. Date Accessed October 16, 2026.

Epinephrine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Epinephrine. Date Accessed October 16, 2026.

Epinephrine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK482160/. Date Accessed October 16, 2026.

Epinephrine Nasal Spray. MedlinePlus. https://medlineplus.gov/druginfo/meds/a624049.html. Date Accessed October 16, 2026.

FDA Roundup: March 7, 2025. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-roundup-march-7-2025. Date Accessed October 16, 2026.