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Nabumetone is a prescription nonsteroidal anti-inflammatory drug used to relieve signs and symptoms of osteoarthritis and rheumatoid arthritis in adults. Current oral tablets contain 500 mg or 750 mg. Nabumetone is converted in the body into an active metabolite responsible for much of its anti-inflammatory and pain-relieving activity.
read more about nabumetone ...Nabumetone is converted to 6-methoxy-2-naphthylacetic acid, which inhibits cyclooxygenase activity and reduces prostaglandin synthesis. Prostaglandins contribute to pain, swelling, and inflammation in affected joints. Reduced prostaglandin production relieves symptoms but does not reverse the underlying joint damage.
Nabumetone is prescribed to adults with symptomatic osteoarthritis or rheumatoid arthritis. Treatment is selected after considering cardiovascular, gastrointestinal, kidney, and bleeding risks. Patients with previous serious allergic reactions to aspirin or other nonsteroidal anti-inflammatory medicines and those undergoing coronary artery bypass graft surgery must not receive it.
The recommended starting dose is 1000 mg by mouth once daily, with or without food. Patients needing greater symptom control can receive 1500 mg to 2000 mg daily in one or two divided doses. Doses greater than 2000 mg daily have not been studied. Treatment uses the lowest appropriate dose for the shortest necessary duration, with adjustments according to symptoms, tolerability, and kidney function.
Nabumetone carries boxed warnings for potentially fatal cardiovascular events, including heart attack and stroke, and serious gastrointestinal bleeding, ulceration, or perforation. Other risks include kidney injury, high blood pressure, heart failure, liver toxicity, severe skin reactions, and fetal kidney problems associated with use during pregnancy. Concurrent use with anticoagulants or other nonsteroidal anti-inflammatory drugs can increase bleeding risk.
Nabumetone relieves signs and symptoms of osteoarthritis and rheumatoid arthritis in adults.
The recommended starting dose is 1000 mg once daily, with or without food.
Daily doses up to 2000 mg have been studied, while doses above that amount have not.
Yes. Its boxed warnings concern serious cardiovascular events and gastrointestinal bleeding, ulcers, or perforation.
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