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Moxifloxacin is a prescription fluoroquinolone antibiotic available in oral, intravenous, and ophthalmic formulations. This page focuses on 400 mg oral tablets. They are indicated for selected bacterial infections in adults age 18 and older, including pneumonia, skin infections, complicated intra-abdominal infections, plague, bacterial sinusitis, and acute bacterial worsening of chronic bronchitis.
read more about moxifloxacin ...Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes involved in DNA replication, repair, and separation. Interfering with these enzymes prevents susceptible bacteria from reproducing and leads to bacterial cell death. Moxifloxacin does not treat infections caused by viruses.
Oral moxifloxacin is used in adults with infections caused by susceptible bacteria, including community-acquired pneumonia and selected skin or abdominal infections. It is also labeled for plague treatment and prevention after exposure. For acute bacterial sinusitis and acute bacterial exacerbations of chronic bronchitis, treatment is reserved for patients without suitable alternative antibiotics because of potentially serious adverse reactions.
The recommended oral dose is 400 mg once every 24 hours. Treatment duration depends on the infection, ranging from five days for acute bacterial exacerbations of chronic bronchitis to 7 to 14 days for community-acquired pneumonia. Complicated skin infections can require 7 to 21 days. Tablets are taken at least four hours before or eight hours after antacids or supplements containing certain minerals, including magnesium, aluminum, iron, or zinc.
Moxifloxacin carries boxed warnings for tendinitis and tendon rupture, peripheral neuropathy, potentially disabling central nervous system effects, and worsening muscle weakness in patients with myasthenia gravis. Other serious risks include QT prolongation, severe allergic reactions, blood glucose disturbances, Clostridioides difficile-associated diarrhea, liver injury, and aortic aneurysm complications in susceptible patients. Treatment is stopped when serious fluoroquinolone reactions develop.
It treats selected bacterial pneumonia, skin and abdominal infections, plague, bacterial sinusitis, and acute bacterial worsening of chronic bronchitis in adults.
The recommended dose is 400 mg once daily, with treatment duration determined by the infection.
Moxifloxacin tablets are taken at least four hours before or eight hours after antacids and certain mineral supplements to prevent reduced absorption.
Yes. The warning covers serious tendon, nerve, and central nervous system reactions and worsening myasthenia gravis.
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