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Modafinil is a prescription wakefulness-promoting medicine and Schedule IV controlled substance. It is indicated to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder. Current oral tablets contain 100 mg or 200 mg. Modafinil does not treat the underlying airway obstruction associated with obstructive sleep apnea.
read more about modafinil ...The exact mechanism responsible for modafinil's wakefulness-promoting effects is not fully established. Modafinil inhibits dopamine reuptake by binding to dopamine transporters and increases extracellular dopamine concentrations in certain brain regions. Its activity also influences other pathways involved in alertness and sleep regulation.
Modafinil is prescribed to adults with excessive sleepiness caused by narcolepsy, obstructive sleep apnea, or shift work disorder. Patients with obstructive sleep apnea continue treatment directed at the underlying airway obstruction, such as continuous positive airway pressure when prescribed. Safety and efficacy have not been established in pediatric patients. Patients with a history of hypersensitivity to modafinil or armodafinil must not receive it.
For narcolepsy or obstructive sleep apnea, the recommended dose is 200 mg by mouth once daily in the morning. For shift work disorder, the recommended dose is 200 mg approximately one hour before the work shift begins. Patients with severe hepatic impairment receive half the usual recommended dose. Although 400 mg daily has been studied, consistent additional benefit over 200 mg has not been demonstrated.
Modafinil can cause serious skin reactions, including Stevens-Johnson syndrome, and potentially life-threatening hypersensitivity reactions. Other concerns include psychiatric symptoms, cardiovascular reactions, insomnia, anxiety, and persistent sleepiness despite treatment. Modafinil can reduce the effectiveness of hormonal contraceptives during treatment and for one month afterward. Patients should be assessed for driving impairment and potential misuse.
Modafinil treats excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work disorder in adults.
The recommended dose is 200 mg once daily in the morning.
The recommended dose is 200 mg approximately one hour before the work shift begins.
Yes. Modafinil can reduce the effectiveness of hormonal contraceptives during treatment and for one month after discontinuation.
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