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Mirtazapine is a prescription antidepressant indicated for major depressive disorder in adults. It is also marketed under the trade name Remeron. Standard oral tablets are available in multiple strengths, including 15 mg, 30 mg, and 45 mg. Mirtazapine is not FDA-approved as a primary treatment for insomnia or for pediatric depression.
read more about mirtazapine ...Mirtazapine increases central noradrenergic and serotonergic activity, partly through antagonism of presynaptic alpha-2 adrenergic receptors. It also blocks certain serotonin receptors and histamine H1 receptors. Its histamine-related activity contributes to sedation and increased appetite. The exact mechanism responsible for its antidepressant effects is not fully established.
Mirtazapine treats adults with major depressive disorder. Healthcare professionals assess depressive symptoms, suicide risk, other medicines, and possible bipolar disorder before treatment. Mirtazapine is not approved for pediatric patients. It must not be combined with monoamine oxidase inhibitors or taken within 14 days of their discontinuation.
The recommended starting dose is 15 mg by mouth once daily, preferably in the evening before sleep. Doses can increase to a maximum of 45 mg daily when clinically indicated. Adjustments should occur at intervals of at least one to two weeks to assess response. Patients with kidney or liver impairment can have reduced clearance. Treatment is gradually tapered when discontinued.
Mirtazapine carries a boxed warning for increased suicidal thoughts and behaviors in children, adolescents, and young adults taking antidepressants. Other serious risks include agranulocytosis, serotonin syndrome, QT prolongation, severe skin reactions, low sodium, and activation of mania or hypomania. Drowsiness, increased appetite, weight gain, and elevated cholesterol or triglycerides can also occur.
Mirtazapine is FDA-approved for major depressive disorder in adults.
The recommended starting dose is 15 mg once daily, preferably in the evening.
The maximum recommended dose is 45 mg once daily.
Yes. Increased appetite and weight gain are recognized adverse reactions, along with drowsiness.
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