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Metoclopramide hydrochloride is a prescription gastrointestinal prokinetic and antiemetic medicine. Current oral tablets contain 5 mg or 10 mg. They are indicated for symptomatic, documented gastroesophageal reflux in adults who have not responded to conventional treatment and for relief of symptoms in adults with acute or recurrent diabetic gastroparesis.
read more about metoclopramide ...Metoclopramide blocks dopamine D2 receptors and acts on serotonin receptors involved in gastrointestinal movement. These actions increase contractions in the upper digestive tract, promote stomach emptying, and reduce nausea and vomiting. Its action at the lower esophageal sphincter can also reduce reflux of stomach contents.
Metoclopramide tablets are used in adults with symptomatic gastroesophageal reflux that has not responded to conventional therapy or with acute or recurrent diabetic gastroparesis. They are not recommended for pediatric patients due to movement disorder risks and methemoglobinemia risk in neonates. Epilepsy, certain gastrointestinal obstructions, and a history of tardive dyskinesia are contraindications.
Adult reflux treatment commonly uses 10 mg to 15 mg by mouth 30 minutes before meals and at bedtime, up to 60 mg daily, for four to 12 weeks. Diabetic gastroparesis treatment uses 10 mg four times daily, up to 40 mg daily. Reflux treatment is limited to 12 weeks, and longer treatment for diabetic gastroparesis is avoided unless unavoidable with continued monitoring. Kidney or liver impairment and certain drug interactions require lower doses.
Metoclopramide carries a boxed warning for tardive dyskinesia, a potentially irreversible movement disorder that becomes more common with longer exposure and higher cumulative doses. Other serious risks include acute dystonia, neuroleptic malignant syndrome, depression and suicidal thoughts, severe restlessness, sedation, and movement disorders resembling Parkinson disease. Treatment is discontinued when symptoms of tardive dyskinesia develop.
They treat selected adult gastroesophageal reflux that has not responded to conventional therapy and symptoms of diabetic gastroparesis.
The recommended dose is 10 mg four times daily before meals and at bedtime, with a 40 mg daily maximum.
Reflux treatment is limited to 12 weeks. For diabetic gastroparesis, treatment longer than 12 weeks is avoided unless unavoidable with continued monitoring.
Yes. The boxed warning concerns tardive dyskinesia, a potentially irreversible movement disorder.
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