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Meclizine hydrochloride is a first-generation antihistamine with antiemetic and antivertigo properties. Current prescription tablets are indicated for vertigo associated with vestibular disorders in adults. Separate over-the-counter and other meclizine products are used to prevent or treat nausea, vomiting, and dizziness associated with motion sickness.
read more about meclizine ...Meclizine blocks histamine H1 receptors and has anticholinergic activity. These actions reduce signaling associated with motion-related nausea and symptoms arising from the vestibular system. Its precise mechanism for relieving vertigo is not fully established.
Prescription meclizine is used in adults with vertigo caused by disorders affecting the vestibular system. Certain motion sickness products are labeled for adults and children age 12 and older. Patients with glaucoma, enlarged prostate, asthma, or conditions that increase susceptibility to sedating medicines require additional caution.
For vertigo, current prescription labeling recommends 25 mg to 100 mg by mouth daily in divided doses, depending on clinical response. For motion sickness, selected products direct 25 mg to 50 mg approximately one hour before travel, with another dose no sooner than 24 hours later when needed. Dosing and age restrictions depend on the product.
Meclizine can cause drowsiness and impair alertness, particularly when taken with alcohol or other central nervous system depressants. Its anticholinergic effects can worsen problems associated with glaucoma or prostate enlargement. Other reported reactions include dry mouth, fatigue, headache, vomiting, blurred vision, and hypersensitivity reactions.
Prescription meclizine treats vertigo associated with vestibular disorders, while selected products prevent or treat motion sickness symptoms.
The recommended adult dosage is 25 mg to 100 mg daily in divided doses.
Selected products direct a dose of 25 mg to 50 mg approximately one hour before travel.
Yes. Meclizine can cause drowsiness, especially with alcohol or other sedating medicines.
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Meclizine. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK501435/. Date Accessed October 14, 2026.
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