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Lyumjev is a prescription rapid-acting insulin containing insulin lispro-aabc. It is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. Current formulations include U-100 and U-200 insulin, containing 100 units or 200 units per mL, respectively.
read more about lyumjev ...Insulin lispro-aabc increases glucose uptake into muscle and fat cells and decreases glucose production by the liver. Its formulation is designed for rapid absorption after subcutaneous injection, allowing use around mealtimes.
Lyumjev is used in adults and pediatric patients who need rapid-acting insulin for diabetes management. Subcutaneous treatment is usually paired with intermediate-acting or long-acting insulin. Doses are individualized according to glucose readings, meals, activity, and other clinical factors.
Lyumjev U-100 or U-200 is injected subcutaneously at the beginning of a meal or within 20 minutes after the meal begins. The number of insulin units is individualized rather than fixed. Only U-100 is used in compatible insulin pumps or for intravenous administration under medical supervision. U-200 must not be used in pumps or given intravenously.
Severe hypoglycemia is the principal serious risk and can cause seizures, unconsciousness, or death. Other concerns include hypokalemia, severe allergic reactions, insulin administration errors, injection-site reactions, lipodystrophy, and localized cutaneous amyloidosis. Blood glucose is monitored closely when insulin regimens change. U-200 must not be transferred from a pen into a syringe, which can cause a dosing error.
Lyumjev improves blood glucose control in adults and pediatric patients with diabetes mellitus.
Subcutaneous Lyumjev is injected at the beginning of a meal or within 20 minutes after eating begins.
U-100 contains 100 insulin units per mL, while U-200 contains 200 units per mL.
No. Current labeling limits insulin pump use to the U-100 formulation.
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Insulin Lispro. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Humalog. Date Accessed October 13, 2026.
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LYUMJEV (insulin lispro-aabc) Prescribing Information. Eli Lilly and Company. https://pi.lilly.com/us/lyumjev-uspi.pdf. Date Accessed October 13, 2026.
Purple Book Search - Lyumjev. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/scripts/purplebooksearch/. Date Accessed October 13, 2026.