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Lovastatin is a prescription HMG-CoA reductase inhibitor, also called a statin. It is used with dietary treatment to reduce elevated cholesterol and lower selected coronary heart disease risks. Current immediate-release tablets include 10 mg, 20 mg, and 40 mg strengths. Certain adolescents age 10 through 17 with heterozygous familial hypercholesterolemia also qualify for treatment.
read more about lovastatin ...Lovastatin inhibits HMG-CoA reductase, an enzyme involved in cholesterol synthesis in the liver. Reduced cholesterol production increases hepatic uptake of low-density lipoprotein cholesterol from the bloodstream.
Lovastatin is used in selected adults with elevated cholesterol or coronary heart disease risk despite dietary measures. It is also labeled for adolescent boys and girls at least one year after menarche, ages 10 through 17, with heterozygous familial hypercholesterolemia meeting specified cholesterol criteria.
The usual adult starting dose for immediate-release tablets is 20 mg once daily with the evening meal. The labeled adult range is 10 mg to 80 mg daily, given once or in two divided doses, with a maximum of 80 mg daily. Adolescents with qualifying familial hypercholesterolemia use 10 mg to 40 mg daily. Certain interacting medicines require substantially lower dose limits or avoidance.
Serious concerns include myopathy and rhabdomyolysis, which can cause kidney injury, as well as liver injury. Strong CYP3A4 inhibitors and active liver disease are contraindications. Current product labeling also lists pregnancy and lactation as contraindications. Unexplained muscle pain, weakness, or dark urine requires prompt medical assessment.
Lovastatin lowers elevated cholesterol and is used for selected coronary heart disease prevention and treatment indications.
The usual starting dose for immediate-release lovastatin is 20 mg once daily with the evening meal.
The maximum labeled adult dose is 80 mg daily, although drug interactions can require lower limits.
Yes. Lovastatin can cause myopathy or rhabdomyolysis, sometimes with kidney injury.
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