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What Is Lorazepam?

Lorazepam is a prescription benzodiazepine and Schedule IV controlled substance. Current oral tablet labeling includes management of anxiety disorders and short-term relief of anxiety symptoms or anxiety associated with depressive symptoms. Tablets are marketed in 0.5 mg, 1 mg, and 2 mg strengths. Injectable lorazepam has separate indications and dosing instructions.

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What Is Lorazepam?

Lorazepam is a prescription benzodiazepine and Schedule IV controlled substance. Current oral tablet labeling includes management of anxiety disorders and short-term relief of anxiety symptoms or anxiety associated with depressive symptoms. Tablets are marketed in 0.5 mg, 1 mg, and 2 mg strengths. Injectable lorazepam has separate indications and dosing instructions.

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How Does Lorazepam Work?

Lorazepam binds to benzodiazepine sites on gamma-aminobutyric acid type A receptors and increases the inhibitory effects of GABA in the central nervous system. This reduces neuronal excitability and produces calming and sedating effects.

Who Is Treated With Oral Lorazepam?

Oral lorazepam is used for anxiety disorders and short-term relief of anxiety symptoms. Its usefulness during treatment lasting longer than four months has not been systematically assessed. Safety and efficacy of oral tablets in children younger than 12 have not been established.

How Is Lorazepam Dosed?

The usual adult oral dose range is 2 mg to 6 mg daily in divided doses, although total daily doses can range from 1 mg to 10 mg. Treatment of anxiety commonly starts at 2 mg to 3 mg daily divided into two or three doses. Older or debilitated adults usually begin with 1 mg to 2 mg daily in divided doses. Dosing is adjusted to clinical response and tolerability.

What Serious Risks Are Linked to Lorazepam?

Lorazepam carries boxed warnings for profound sedation, respiratory depression, coma, and death when combined with opioids, as well as abuse, misuse, addiction, physical dependence, and withdrawal. Abrupt discontinuation can cause life-threatening withdrawal seizures and other reactions. Alcohol and other sedatives can intensify impairment.

Frequently Asked Questions About Lorazepam

What conditions does oral lorazepam treat?

Current tablet labeling includes anxiety disorders and short-term relief of anxiety symptoms.

What is a common adult starting dose for anxiety?

An initial dose of 2 mg to 3 mg daily divided into two or three doses is common.

Is lorazepam a controlled substance?

Yes. Lorazepam is a Schedule IV controlled substance.

Can lorazepam be stopped suddenly?

No. Abrupt discontinuation after continued use can cause serious withdrawal reactions, including seizures, so gradual dose reduction is recommended.

References

DailyMed - LORAZEPAM tablet. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=46af8e93-3169-408a-b4d8-b8498642801d. Date Accessed October 13, 2026.

Lorazepam. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548563/. Date Accessed October 13, 2026.

Lorazepam. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682053.html. Date Accessed October 13, 2026.

Lorazepam. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lorazepam. Date Accessed October 13, 2026.

Lorazepam. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK532890/. Date Accessed October 13, 2026.