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Lisdexamfetamine dimesylate is a prescription central nervous system stimulant and Schedule II controlled substance. It is indicated for attention-deficit/hyperactivity disorder in adults and children age 6 and older and for moderate to severe binge eating disorder in adults. Current products include oral capsules and chewable tablets. It is not indicated for weight loss.
read more about lisdexamfetamine ...Lisdexamfetamine is a prodrug that is converted in the body to dextroamphetamine. Amphetamines increase norepinephrine and dopamine activity by reducing their reuptake and promoting their release. The exact therapeutic mechanism in attention-deficit/hyperactivity disorder and binge eating disorder is not established.
Lisdexamfetamine is used for attention-deficit/hyperactivity disorder from age 6 and for moderate to severe binge eating disorder in adults. Use in children younger than 6 is not recommended. Patients are assessed for cardiac disease and risk of misuse or addiction before treatment. Monoamine oxidase inhibitors used currently or within the previous 14 days are contraindicated.
Both labeled conditions start at 30 mg by mouth once each morning. For attention-deficit/hyperactivity disorder, the dose can increase by 10 mg or 20 mg at approximately weekly intervals to 30 mg to 70 mg daily. For adult binge eating disorder, dosing increases by 20 mg at approximately weekly intervals to a target of 50 mg to 70 mg daily. The maximum dose is 70 mg daily.
Lisdexamfetamine carries a boxed warning for abuse, misuse, and addiction, including overdose and death. Other serious concerns include sudden death in patients with serious heart disease, increased blood pressure and heart rate, psychiatric reactions, slowed growth in children, peripheral vasculopathy, serotonin syndrome, and seizures. Height, weight, blood pressure, pulse, and behavioral symptoms are monitored during treatment.
It treats attention-deficit/hyperactivity disorder from age 6 and moderate to severe binge eating disorder in adults.
The recommended starting dose is 30 mg once daily in the morning.
The maximum recommended dose is 70 mg daily.
Yes. The boxed warning concerns abuse, misuse, addiction, and the risk of overdose or death.
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Lisdexamfetamine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a607047.html. Date Accessed October 13, 2026.
Lisdexamfetamine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lisdexamfetamine. Date Accessed October 13, 2026.
LISDEXAMFETAMINE DIMESYLATE. FDA Global Substance Registration System. https://precision.fda.gov/ginas/app/ui/substances/1794a4ca-4ee4-41f0-bf7a-6ca9640cb4d4. Date Accessed October 13, 2026.