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Linezolid is a prescription oxazolidinone antibacterial. Current U.S. labeling includes nosocomial pneumonia, community-acquired pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections caused by susceptible Gram-positive bacteria. It has no clinical activity against Gram-negative pathogens.
read more about linezolid ...Linezolid binds to bacterial 23S ribosomal RNA of the 50S subunit and prevents formation of a functional 70S initiation complex. This blocks an early step in bacterial protein synthesis.
Linezolid is used in adults and pediatric patients for labeled infections caused by susceptible Gram-positive organisms. Culture and susceptibility information guide therapy when available. Treatment for a proven or strongly suspected Gram-negative infection requires separate antibacterial therapy.
Adults and adolescents age 12 and older commonly receive 600 mg by mouth every 12 hours for pneumonia, complicated skin infections, and vancomycin-resistant Enterococcus faecium infection. Uncomplicated skin infection in adults uses 400 mg every 12 hours. Treatment duration depends on the infection. Younger pediatric patients use weight-based dosing.
Serious concerns include myelosuppression, peripheral and optic neuropathy, serotonin syndrome, lactic acidosis, severe hyponatremia, and hypoglycemia in patients taking insulin or other glucose-lowering medicines. Complete blood counts are monitored weekly, especially during longer courses. Monoamine oxidase inhibitors taken within the previous two weeks are contraindicated.
Current labeling includes selected Gram-positive pneumonias, skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections.
Several labeled adult infections use 600 mg every 12 hours, while uncomplicated skin infection uses 400 mg every 12 hours.
Yes. Linezolid can contribute to serotonin syndrome when combined with certain serotonergic medicines, so current labeling includes specific restrictions and monitoring instructions.
No. Linezolid has no clinical activity against Gram-negative pathogens.
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Linezolid. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548245/. Date Accessed October 13, 2026.
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Linezolid. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Linezolid. Date Accessed October 13, 2026.
Linezolid. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK539793/. Date Accessed October 13, 2026.