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What Is Lexette?

Lexette is a prescription topical corticosteroid foam containing halobetasol propionate 0.05 percent. It is indicated for plaque psoriasis in patients age 12 and older. Each gram contains 0.5 mg of halobetasol propionate.

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What Is Lexette?

Lexette is a prescription topical corticosteroid foam containing halobetasol propionate 0.05 percent. It is indicated for plaque psoriasis in patients age 12 and older. Each gram contains 0.5 mg of halobetasol propionate.

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How Does Lexette Work?

Halobetasol activates glucocorticoid receptors and reduces inflammatory signaling in the skin. Topical corticosteroids also constrict small blood vessels and suppress immune activity in treated areas.

Who Is Treated With Lexette?

Lexette is used on affected skin in patients age 12 and older with plaque psoriasis. It is not used in the eyes, mouth, or vagina, and treatment avoids the face, groin, and underarms unless a prescriber directs otherwise.

How Is Lexette Applied?

A thin layer is applied to affected skin twice daily. Treatment beyond two weeks is not recommended, and the total amount does not exceed 50 grams per week. Treated areas are not covered with occlusive dressings unless directed by a clinician.

What Serious Risks Are Linked to Lexette?

Systemic absorption can suppress the hypothalamic-pituitary-adrenal axis and cause Cushing syndrome, high blood glucose, or adrenal insufficiency. Local reactions, glaucoma, cataracts, skin infection, and allergic contact dermatitis can occur. The foam is flammable, so heat, flame, and smoking are avoided during and immediately after application.

Frequently Asked Questions About Lexette

What does Lexette treat?

Lexette treats plaque psoriasis in patients age 12 and older.

How frequently is Lexette applied?

A thin layer is applied to affected skin twice daily.

How long is Lexette used?

Current labeling does not recommend treatment beyond two weeks.

What is the weekly amount limit?

The total amount does not exceed 50 grams per week.

References

DailyMed - LEXETTE (halobetasol propionate) topical foam. https://www.dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8aa1f819-c81f-4af1-aaa7-353df3203ff6&type=display. Date Accessed October 13, 2026.

Halobetasol Cream. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK544234/. Date Accessed October 13, 2026.

Halobetasol Propionate. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/6918178. Date Accessed October 13, 2026.

Halobetasol Topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601060.html. Date Accessed October 13, 2026.

Topical Corticosteroids. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK532940/. Date Accessed October 13, 2026.