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Levocetirizine is a second-generation H1 antihistamine. Current prescription labeling includes relief of symptoms associated with perennial allergic rhinitis and treatment of uncomplicated skin manifestations of chronic idiopathic urticaria. Current nonprescription 5 mg tablets temporarily relieve hay fever and other respiratory allergy symptoms.
read more about levocetirizine ...Levocetirizine is the active R-enantiomer of cetirizine and selectively blocks peripheral histamine H1 receptors. Blocking histamine reduces symptoms such as itching, sneezing, runny nose, and watery eyes.
Prescription tablets treat chronic idiopathic urticaria in adults and children age 6 and older. Prescription liquid also includes chronic idiopathic urticaria from age 6 months and perennial allergic rhinitis in children age 6 months through 2 years. Kidney function affects whether and how levocetirizine is used.
Adults and children age 12 and older commonly receive 5 mg once daily in the evening, although 2.5 mg controls symptoms in some patients. Children age 6 through 11 receive 2.5 mg once daily in the evening. Younger children use age-specific liquid doses. Adults and adolescents with reduced kidney function require lower or less frequent dosing.
Levocetirizine can cause somnolence, fatigue, and reduced alertness, especially with alcohol or other central nervous system depressants. Urinary retention can occur in susceptible patients. Severe new itching has been reported within days after stopping long-term levocetirizine. End-stage kidney disease requiring dialysis is a contraindication under prescription labeling.
Prescription labeling includes perennial allergic rhinitis and chronic idiopathic urticaria under formulation- and age-specific criteria.
The usual prescription dose is 5 mg once daily in the evening, although some patients are controlled with 2.5 mg.
Yes. Reduced kidney function requires lower or less frequent dosing in patients age 12 and older, and some renal conditions are contraindications.
Yes. New severe itching has been reported after discontinuation, usually following long-term use.
DailyMed - LEVOCETIRIZINE DIHYDROCHLORIDE tablet. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d8b4b326-8be1-4404-9db7-636d86933139. Date Accessed October 12, 2026.
FDA Requires Warning About Rare but Severe Itching After Stopping Long-Term Use of Oral Allergy Medicines Cetirizine or Levocetirizine. U.S. Food and Drug Administration. https://www.fda.gov/drugs/drug-safety-communications/fda-requires-warning-about-rare-severe-itching-after-stopping-long-term-use-oral-allergy-medicines. Date Accessed October 12, 2026.
Levocetirizine. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK501598/. Date Accessed October 12, 2026.
Levocetirizine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a607056.html. Date Accessed October 12, 2026.
Levocetirizine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/1549000. Date Accessed October 12, 2026.