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Letrozole is a prescription aromatase inhibitor used in postmenopausal women with selected hormone-sensitive breast cancers. Current tablets contain 2.5 mg. Labeling includes adjuvant treatment of hormone receptor-positive early breast cancer, extended adjuvant treatment after prior tamoxifen, and first- or second-line treatment of selected advanced breast cancer.
read more about letrozole ...Letrozole inhibits aromatase, the enzyme that converts adrenal androgens to estrogens in peripheral tissues. Lower estrogen concentrations reduce stimulation of estrogen-dependent breast cancer cells.
Letrozole is used in postmenopausal women with hormone receptor-positive early breast cancer, selected early breast cancer after prior adjuvant tamoxifen, or hormone receptor-positive or unknown advanced breast cancer under current labeling. Pregnancy and known hypersensitivity are contraindications.
The recommended dose is 2.5 mg by mouth once daily with or without food. Patients with cirrhosis and severe hepatic impairment receive 2.5 mg every other day. Advanced breast cancer treatment continues until tumor progression.
Letrozole can reduce bone mineral density and increase fracture and osteoporosis risk. It can also increase cholesterol and cause fatigue, dizziness, and somnolence. Letrozole can cause fetal harm and is contraindicated during pregnancy.
Letrozole treats selected early and advanced breast cancers in postmenopausal women.
The recommended dose is 2.5 mg once daily.
Yes. Patients with cirrhosis and severe hepatic impairment receive 2.5 mg every other day.
Yes. Letrozole can reduce bone mineral density and increase osteoporosis and fracture risk.
DailyMed - LETROZOLE tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cb1da0ac-8db1-4482-824d-430511d1b7a0. Date Accessed October 12, 2026.
Letrozole. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548381/. Date Accessed October 12, 2026.
Letrozole. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a698004.html. Date Accessed October 12, 2026.
Letrozole. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/letrozole. Date Accessed October 12, 2026.
Letrozole. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Letrozole. Date Accessed October 12, 2026.