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What Is Latanoprost?

Latanoprost 0.005 percent eye drops is a prescription prostaglandin F2 alpha analogue used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. The eye drops contain 50 mcg of latanoprost per mL.

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What Is Latanoprost?

Latanoprost 0.005 percent eye drops is a prescription prostaglandin F2 alpha analogue used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. The eye drops contain 50 mcg of latanoprost per mL.

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How Does Latanoprost Lower Eye Pressure?

Latanoprost is converted in the cornea to an active acid form that increases outflow of aqueous humor, mainly through the uveoscleral pathway. Increased fluid outflow lowers intraocular pressure.

Who Is Treated With Latanoprost?

Latanoprost is used in patients with open-angle glaucoma or ocular hypertension who need lower intraocular pressure. Safety and efficacy are not established in pediatric patients under current generic U.S. labeling.

How Is Latanoprost Used?

One drop is placed in the affected eye or eyes once daily in the evening. More frequent administration can reduce the pressure-lowering effect. When another topical eye medicine is used, the products are administered at least five minutes apart.

What Serious Risks Are Linked to Latanoprost?

Latanoprost can increase brown pigmentation of the iris, and the iris color change is considered permanent. It can also darken eyelid skin, change eyelash growth, cause intraocular inflammation, contribute to macular edema, reactivate herpetic keratitis, and lead to bacterial keratitis if the bottle tip becomes contaminated. Contact lenses are removed before dosing and can be reinserted after 15 minutes.

Frequently Asked Questions About Latanoprost

What conditions does latanoprost treat?

Latanoprost lowers elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

How frequently is latanoprost used?

One drop is placed in the affected eye or eyes once daily in the evening.

Can latanoprost permanently change eye color?

Yes. Increased brown iris pigmentation can occur and is considered permanent.

Are pediatric safety and efficacy established?

No. Current generic U.S. labeling states that safety and efficacy in pediatric patients have not been established.

References

DailyMed - LATANOPROST ophthalmic solution. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=821d2ad5-a430-4fd2-8cfd-50b2118b8639. Date Accessed October 8, 2026.

Latanoprost. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK501675/. Date Accessed October 8, 2026.

Latanoprost. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a697003.html. Date Accessed October 8, 2026.

Latanoprost. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Latanoprost. Date Accessed October 8, 2026.

Latanoprost. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK540978/. Date Accessed October 8, 2026.