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What Is Lansoprazole?

Lansoprazole is a prescription proton pump inhibitor sold as delayed-release capsules in 15 mg and 30 mg strengths. Current labeling includes treatment and prevention of selected duodenal and gastric ulcers, gastroesophageal reflux disease, erosive esophagitis, Helicobacter pylori eradication regimens, and pathological hypersecretory conditions.

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What Is Lansoprazole?

Lansoprazole is a prescription proton pump inhibitor sold as delayed-release capsules in 15 mg and 30 mg strengths. Current labeling includes treatment and prevention of selected duodenal and gastric ulcers, gastroesophageal reflux disease, erosive esophagitis, Helicobacter pylori eradication regimens, and pathological hypersecretory conditions.

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How Does Lansoprazole Reduce Stomach Acid?

Lansoprazole suppresses gastric acid secretion by inhibiting the hydrogen-potassium ATPase enzyme system in gastric parietal cells. This blocks the final step of acid production and raises gastric pH.

Who Is Treated With Lansoprazole?

Lansoprazole is used in adults for several acid-related gastrointestinal disorders. Pediatric labeling includes short-term treatment of symptomatic gastroesophageal reflux disease and erosive esophagitis from age 1 through 17. Safety and efficacy are not established below age 1 for these uses.

How Is Lansoprazole Dosed?

Adult symptomatic gastroesophageal reflux disease uses 15 mg once daily for up to eight weeks, while erosive esophagitis uses 30 mg once daily for up to eight weeks. Children age 1 through 11 receive 15 mg once daily when body weight is 30 kg or less and 30 mg once daily when body weight is above 30 kg. Capsules are taken before meals.

What Serious Risks Are Linked to Lansoprazole?

Serious concerns include acute tubulointerstitial nephritis, Clostridioides difficile-associated diarrhea, bone fracture risk with prolonged or high-dose therapy, severe cutaneous reactions, lupus, vitamin B12 deficiency, and low magnesium with related calcium or potassium abnormalities. Rilpivirine-containing products are contraindicated with lansoprazole.

Frequently Asked Questions About Lansoprazole

What conditions does lansoprazole treat?

Current labeling includes selected ulcers, gastroesophageal reflux disease, erosive esophagitis, Helicobacter pylori eradication regimens, and pathological hypersecretory conditions.

What is the usual adult dose for symptomatic gastroesophageal reflux disease?

The recommended dose is 15 mg once daily for up to eight weeks.

Can children take lansoprazole?

Yes. Current prescription labeling includes short-term treatment of symptomatic gastroesophageal reflux disease and erosive esophagitis from age 1 through 17.

When should lansoprazole be taken?

Delayed-release capsules are taken before meals.

References

DailyMed - LANSOPRAZOLE capsule, delayed release. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75691c2d-2265-4153-bc3a-4f7d5d51e250. Date Accessed October 8, 2026.

Lansoprazole. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548452/. Date Accessed October 8, 2026.

Lansoprazole. MedlinePlus. https://medlineplus.gov/druginfo/meds/a695020.html. Date Accessed October 8, 2026.

Lansoprazole. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lansoprazole. Date Accessed October 8, 2026.

Proton Pump Inhibitors (PPI). StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557385/. Date Accessed October 8, 2026.