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Lamotrigine is a prescription antiseizure medicine also used for maintenance treatment of bipolar I disorder. Current immediate-release labeling includes adjunctive therapy for partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome from age 2, plus selected conversion to monotherapy for partial-onset seizures from age 16.
read more about lamotrigine ...The exact therapeutic mechanisms are not established. Lamotrigine inhibits voltage-sensitive sodium channels in laboratory studies and reduces release of excitatory neurotransmitters, including glutamate.
Lamotrigine is used for labeled seizure disorders under age- and regimen-specific criteria. In adults with bipolar I disorder, it is used as maintenance treatment to delay future mood episodes after acute treatment. Current labeling does not recommend lamotrigine for acute manic or mixed episodes.
Dosing depends on age, indication, valproate use, enzyme-inducing medicines, and estrogen-containing products. In adults with epilepsy who are not taking valproate or enzyme inducers, adjunctive treatment commonly starts at 25 mg once daily for two weeks, then 50 mg daily for two weeks before further increases. Doses are lower with valproate and higher with enzyme-inducing antiseizure medicines.
Lamotrigine carries a boxed warning for serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Other serious concerns include hemophagocytic lymphohistiocytosis, DRESS with organ failure, cardiac rhythm abnormalities in patients with certain heart disorders, blood dyscrasias, suicidal thoughts or behavior, aseptic meningitis, and withdrawal seizures.
Current immediate-release labeling includes selected seizure disorders and maintenance treatment of bipolar I disorder.
Yes. Valproate slows lamotrigine clearance, so lower starting doses and slower titration are used.
Yes. Estrogen-containing products can reduce lamotrigine concentrations, and starting or stopping them can require dose adjustment.
Yes. The boxed warning concerns serious skin rashes that can become life threatening.
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Lamotrigine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548562/. Date Accessed October 8, 2026.
Lamotrigine. MedlinePlus. https://medlineplus.gov/druginfo/meds/a695007.html. Date Accessed October 8, 2026.
Lamotrigine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lamotrigine. Date Accessed October 8, 2026.
Lamotrigine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK470442/. Date Accessed October 8, 2026.