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Lacosamide is a prescription antiseizure medicine and Schedule V controlled substance. Current U.S. labeling includes partial-onset seizures in patients age 1 month and older and adjunctive treatment of primary generalized tonic-clonic seizures in patients age 4 and older. Oral tablets, oral solution, and intravenous injection are available.
read more about lacosamide ...The exact mechanism responsible for the antiseizure effect is not established. Laboratory studies show that lacosamide selectively increases slow inactivation of voltage-gated sodium channels, which stabilizes hyperexcitable neuronal membranes without affecting fast inactivation.
Lacosamide is used as monotherapy or adjunctive therapy for partial-onset seizures from age 1 month. It is also used as adjunctive therapy for primary generalized tonic-clonic seizures from age 4. Pediatric oral doses are based on body weight.
Adults age 17 and older starting monotherapy for partial-onset seizures receive 100 mg twice daily. Adults starting adjunctive therapy for partial-onset or primary generalized tonic-clonic seizures receive 50 mg twice daily. The maximum recommended adult maintenance dose is 200 mg twice daily. Kidney or liver impairment can require dose changes.
Serious concerns include suicidal thoughts or behavior, dizziness, ataxia, PR interval prolongation, atrioventricular block, ventricular arrhythmias, syncope, and DRESS with multiorgan involvement. Lacosamide is withdrawn gradually over at least one week to reduce the risk of increased seizures.
Current labeling includes partial-onset seizures and adjunctive treatment of primary generalized tonic-clonic seizures under age-specific criteria.
The recommended starting dose is 100 mg twice daily.
The recommended starting dose is 50 mg twice daily.
Yes. Lacosamide can prolong cardiac conduction and has been associated with atrioventricular block and ventricular arrhythmias.
DailyMed - LACOSAMIDE tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ecb8b33e-7cbd-4f5e-9fe9-e72dff9bcb86. Date Accessed October 8, 2026.
Lacosamide. Drugs and Lactation Database (LactMed). https://www.ncbi.nlm.nih.gov/books/NBK500748/. Date Accessed October 8, 2026.
Lacosamide. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK547940/. Date Accessed October 8, 2026.
Lacosamide. MedlinePlus. https://medlineplus.gov/druginfo/meds/a609028.html. Date Accessed October 8, 2026.
Lacosamide. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Lacosamide. Date Accessed October 8, 2026.