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Kloxxado is a prescription opioid antagonist nasal spray containing naloxone hydrochloride. It is indicated for emergency treatment of known or suspected opioid overdose with respiratory or central nervous system depression in adults and children. Each single-dose spray contains 8 mg of naloxone hydrochloride in 0.1 mL.
read more about kloxxado ...Naloxone competes with opioids for opioid receptor sites and reverses opioid effects, including respiratory and central nervous system depression. Its action can wear off before the opioid has cleared from the body.
Kloxxado is used when an opioid overdose is known or suspected in an adult or child. It is intended for immediate emergency use when opioids could be present. Emergency medical care is sought immediately after the first dose.
One spray is given into one nostril. If the person does not respond within two to three minutes, or responds and then returns to respiratory depression, another dose is given with a new device in the alternate nostril. Additional doses can be given every two to three minutes until emergency medical help arrives.
Opioid effects can return after an initial response to naloxone, so continued observation and repeat dosing can be necessary. Reversal can be incomplete with partial opioid agonists such as buprenorphine. In people who are physically dependent on opioids, naloxone can precipitate acute withdrawal.
Kloxxado is used for emergency treatment of known or suspected opioid overdose in adults and children.
Each single-dose nasal spray contains 8 mg of naloxone hydrochloride in 0.1 mL.
Another dose can be given after two to three minutes if there is no response or if respiratory depression returns.
No. Emergency medical care is sought immediately after Kloxxado is administered.
DailyMed - KLOXXADO (naloxone hydrochloride) spray. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ebf0f833-c1c0-487c-8f29-01fa8c61b6cb. Date Accessed October 8, 2026.
KLOXXADO (naloxone hydrochloride) Prescribing Information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/212045s005lbl.pdf. Date Accessed October 8, 2026.
Naloxone. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Naloxone. Date Accessed October 8, 2026.
Naloxone. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK441910/. Date Accessed October 8, 2026.
Naloxone Nasal Spray. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a616003.html. Date Accessed October 8, 2026.