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Ketorolac tromethamine ophthalmic is a prescription nonsteroidal anti-inflammatory eye medicine. Current 0.5 percent eye drops are indicated for temporary relief of ocular itching from seasonal allergic conjunctivitis and for inflammation after cataract surgery. A 0.4 percent formulation has separate labeling for pain and burning or stinging after corneal refractive surgery.
read more about ketorolac ophthalmic ...Ketorolac inhibits cyclooxygenase activity and reduces prostaglandin synthesis. Lower prostaglandin activity reduces inflammation and pain in treated ocular tissues.
Ketorolac ophthalmic 0.5 percent is used for seasonal allergic eye itching and postoperative inflammation after cataract extraction. Ketorolac ophthalmic 0.4 percent is used for pain and burning or stinging after corneal refractive surgery. Hypersensitivity to a formulation ingredient is a contraindication.
For seasonal allergic itching, the 0.5 percent drops are used as one drop in the affected eye or eyes four times daily. After cataract surgery, one drop is used four times daily beginning 24 hours after surgery and continuing through the first two postoperative weeks. The 0.4 percent drops use one drop in the operated eye four times daily as needed for up to four days after corneal refractive surgery.
Topical ketorolac can delay healing and increase ocular bleeding. Serious corneal reactions include keratitis, epithelial breakdown, thinning, erosion, ulceration, and perforation, which can threaten vision. Cross-sensitivity can occur in patients with reactions to aspirin or other nonsteroidal anti-inflammatory drugs. Contact lenses are removed before administration.
It treats seasonal allergic eye itching and inflammation after cataract surgery under current labeling.
One drop is placed in the affected eye four times daily beginning 24 hours after surgery and continuing through the first two postoperative weeks.
It is used for pain and burning or stinging after corneal refractive surgery.
Yes. Topical nonsteroidal anti-inflammatory medicines can cause serious corneal injury, including ulceration and perforation.
Clinical Evaluation of Ketorolac Tromethamine 0.5% Ophthalmic Solution for the Treatment of Seasonal Allergic Conjunctivitis. https://pubmed.ncbi.nlm.nih.gov/8236005/. Date Accessed October 7, 2026.
Double-Masked, Paired-Comparison Clinical Study of Ketorolac Tromethamine 0.5% Ophthalmic Solution Compared With Placebo Eyedrops in the Treatment of Seasonal Allergic Conjunctivitis. https://pubmed.ncbi.nlm.nih.gov/8236004/. Date Accessed October 7, 2026.
Efficacy and Safety of Ketorolac Tromethamine 0.5% and Levocabastine 0.05%: A Multicenter Comparison in Patients With Seasonal Allergic Conjunctivitis. https://pubmed.ncbi.nlm.nih.gov/11010060/. Date Accessed October 7, 2026.
Ketorolac Ophthalmic: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a601241.html. Date Accessed October 7, 2026.
Ketorolac Tromethamine Ophthalmic Solution 0.5% Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d9a186ba-74a9-b6d4-1109-1e045ba1763e. Date Accessed October 7, 2026.