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Ketoprofen is a prescription nonsteroidal anti-inflammatory drug. Current immediate-release capsule labeling includes rheumatoid arthritis, osteoarthritis, pain, and primary dysmenorrhea. Active U.S. capsule products remain listed in current labeling.
read more about ketoprofen ...Ketoprofen inhibits cyclooxygenase activity and reduces prostaglandin synthesis. Lower prostaglandin production decreases inflammation, pain, and fever associated with susceptible conditions.
Ketoprofen capsules are used for signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea. The lowest dose needed for the shortest treatment duration is used to reduce nonsteroidal anti-inflammatory drug risks.
Rheumatoid arthritis and osteoarthritis usually start at 75 mg three times daily or 50 mg four times daily. Mild to moderate pain and primary dysmenorrhea use 25 mg to 50 mg every six to eight hours as needed. The recommended maximum for immediate-release capsules is 300 mg per day.
Ketoprofen carries boxed warnings for serious cardiovascular thrombotic events and gastrointestinal bleeding, ulceration, and perforation. Other serious concerns include kidney injury, high blood pressure, heart failure, liver injury, severe skin reactions, anaphylaxis, blood-cell abnormalities, and fetal toxicity. Use during coronary artery bypass graft surgery is contraindicated.
Ketoprofen treats selected arthritis symptoms, mild to moderate pain, and primary dysmenorrhea.
The usual dose is 25 mg to 50 mg every six to eight hours as needed.
The recommended maximum is 300 mg per day.
Yes. The boxed warnings concern serious cardiovascular thrombotic events and gastrointestinal bleeding, ulceration, and perforation.
A Double-Blind Crossover Evaluation of Ketoprofen (Orudis) and Placebo in Rheumatoid Arthritis With Assessment of Long-Term Tolerance. https://pubmed.ncbi.nlm.nih.gov/357231/. Date Accessed October 7, 2026.
Double-Blind Crossover Comparison of Ketoprofen, Naproxen, and Placebo in Patients With Primary Dysmenorrhea. https://pubmed.ncbi.nlm.nih.gov/2268862/. Date Accessed October 7, 2026.
Ketoprofen Capsules Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=492de5dc-7c1b-47be-8510-43be4e1fd4ed. Date Accessed October 7, 2026.
Ketoprofen in the Treatment of Rheumatoid Arthritis. Double-Blind, Cross-Over Placebo Comparison. https://pubmed.ncbi.nlm.nih.gov/790545/. Date Accessed October 7, 2026.
Ketoprofen: MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a686014.html. Date Accessed October 7, 2026.