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Kenalog-40 is a prescription triamcinolone acetonide injectable suspension containing 40 mg per mL. It is a long-acting corticosteroid formulation labeled for deep intramuscular and intra-articular administration. It is not used intravenously, intradermally, intraocularly, epidurally, or intrathecally.
read more about kenalog40 ...Triamcinolone acetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity. Glucocorticoid receptor activity changes expression of inflammatory and immune-response genes and reduces inflammatory activity in susceptible conditions.
Intramuscular Kenalog-40 is used for selected allergic, dermatologic, endocrine, gastrointestinal, hematologic, kidney, respiratory, rheumatic, and other corticosteroid-responsive disorders when oral therapy is not feasible. Intra-articular treatment is used as short-term adjunctive therapy for selected joint and soft tissue inflammatory conditions.
The suggested initial systemic dose is 60 mg injected deeply into the gluteal muscle, with usual adjustment from 40 mg to 80 mg according to response. Intra-articular initial doses are 2.5 mg to 5 mg for smaller joints and 5 mg to 15 mg for larger joints, with higher local doses used in some adults.
Serious concerns include anaphylaxis, adrenal suppression, severe infections, blood pressure elevation, fluid retention, glucose changes, osteoporosis, psychiatric reactions, glaucoma, and local tissue atrophy. Epidural administration is not approved and has been linked to spinal cord infarction, paralysis, blindness, stroke, and death.
Kenalog-40 contains 40 mg of triamcinolone acetonide per mL.
Kenalog-40 is labeled for intramuscular or intra-articular administration.
The label lists 60 mg by deep gluteal intramuscular injection as the suggested initial systemic dose.
No. Current labeling directs against intravenous and epidural administration.
Comparison of High- and Low-Dose Intra-Articular Triamcinolone Acetonide Injection for Treatment of Primary Shoulder Stiffness: A Prospective Randomized Trial. https://pubmed.ncbi.nlm.nih.gov/27914846/. Date Accessed October 7, 2026.
Effect of Intramuscular vs Intra-Articular Glucocorticoid Injection on Pain Among Adults With Knee Osteoarthritis: The KIS Randomized Clinical Trial. https://pubmed.ncbi.nlm.nih.gov/35380645/. Date Accessed October 7, 2026.
KENALOG-40 (Triamcinolone Acetonide) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cf970688-cd77-b95c-4bd9-c541590e9722. Date Accessed October 7, 2026.
The Efficacy of Intra-Articular Triamcinolone Acetonide 10 mg vs. 40 mg in Patients With Knee Osteoarthritis: A Non-Inferiority, Randomized, Controlled, Double-Blind, Multicenter Study. https://pubmed.ncbi.nlm.nih.gov/36737698/. Date Accessed October 7, 2026.
Triamcinolone Injection: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a625028.html. Date Accessed October 7, 2026.