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Jolessa is a prescription extended-cycle combination oral contraceptive containing levonorgestrel and ethinyl estradiol. It is indicated for females of reproductive potential to prevent pregnancy. Each 91-day pack contains 84 active pink tablets followed by 7 white inert tablets.
read more about jolessa ...Jolessa prevents pregnancy primarily by suppressing ovulation. Its active tablets combine the progestin levonorgestrel with the estrogen ethinyl estradiol.
Jolessa is used by females of reproductive potential who choose a combined oral contraceptive for pregnancy prevention. It is contraindicated in patients with a high risk of arterial or venous thrombosis, current or previous breast cancer, selected liver disease, unexplained uterine bleeding, and certain interacting hepatitis C regimens.
One tablet is taken by mouth at the same time every day. The regimen uses one active tablet containing 0.15 mg of levonorgestrel and 0.03 mg of ethinyl estradiol daily for 84 days, followed by one inert tablet daily for 7 days. The next 91-day course begins immediately after the last inert tablet.
Jolessa carries a boxed warning for cigarette smoking and serious cardiovascular events. It is contraindicated in patients older than 35 who smoke. Other serious concerns include blood clots, stroke, heart attack, high blood pressure, liver disease, gallbladder disease, and abnormal uterine bleeding.
Each active tablet contains 0.15 mg of levonorgestrel and 0.03 mg of ethinyl estradiol.
One cycle lasts 91 days with 84 active tablets followed by 7 inert tablets.
Yes. The boxed warning concerns cigarette smoking and serious cardiovascular events.
No. Jolessa does not protect against HIV or other sexually transmitted infections.
A Multicenter, Randomized Study of an Extended Cycle Oral Contraceptive. https://pubmed.ncbi.nlm.nih.gov/12954519/. Date Accessed October 6, 2026.
Endometrial Microstructure After Long-Term Use of a 91-Day Extended-Cycle Oral Contraceptive Regimen. https://pubmed.ncbi.nlm.nih.gov/15639074/. Date Accessed October 6, 2026.
Ethinyl Estradiol and Levonorgestrel (Oral Contraceptives): MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a625049.html. Date Accessed October 6, 2026.
Jolessa: Package Insert and Prescribing Information. https://www.drugs.com/pro/jolessa.html. Date Accessed October 6, 2026.
U.S. Selected Practice Recommendations for Contraceptive Use, 2024. https://www.cdc.gov/mmwr/volumes/73/rr/rr7303a1.htm. Date Accessed October 6, 2026.