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Itraconazole is a prescription triazole antifungal medicine. Current 100 mg capsules treat blastomycosis, histoplasmosis, selected aspergillosis, and dermatophyte onychomycosis of the toenails or fingernails under labeled criteria.
read more about itraconazole ...Itraconazole inhibits fungal cytochrome P450-dependent synthesis of ergosterol, a component of fungal cell membranes. Disruption of ergosterol synthesis interferes with fungal cell membrane structure and function.
Itraconazole capsules treat pulmonary or extrapulmonary blastomycosis, histoplasmosis, and pulmonary or extrapulmonary aspergillosis in patients who cannot tolerate or have not responded to amphotericin B. They also treat dermatophyte onychomycosis in non-immunocompromised patients after laboratory confirmation.
Blastomycosis and histoplasmosis start at 200 mg once daily and can increase to 400 mg daily. Aspergillosis uses 200 mg to 400 mg daily. Toenail onychomycosis uses 200 mg once daily for 12 weeks, while fingernail onychomycosis uses two one-week courses of 200 mg twice daily separated by three weeks without itraconazole. Capsules are taken with a full meal.
Itraconazole capsules carry boxed warnings for congestive heart failure, cardiac effects, and serious drug interactions. Other concerns include liver toxicity, peripheral edema, hearing loss, severe skin reactions, and neuropathy. Capsules and the oral liquid are different formulations and are not interchangeable.
Current labeling includes blastomycosis, histoplasmosis, selected aspergillosis, and dermatophyte onychomycosis.
The labeled regimen is 200 mg once daily for 12 consecutive weeks.
Capsules are swallowed whole with a full meal.
Yes. The boxed warning covers congestive heart failure, cardiac effects, and serious drug interactions.
Itraconazole Capsules Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=23126370-8d6a-4027-bd8f-860e2776ba3a. Date Accessed October 5, 2026.
Itraconazole: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a692049.html. Date Accessed October 5, 2026.
Itraconazole. https://www.ncbi.nlm.nih.gov/books/NBK557874/. Date Accessed October 5, 2026.
SPORANOX (Itraconazole) Capsules Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a4d555fa-787c-40fb-bb7d-b0d4f7318fd0. Date Accessed October 5, 2026.
TOLSURA (Itraconazole) Capsules Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=human&query=TOLSURA. Date Accessed October 5, 2026.