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Isosorbide dinitrate is a prescription organic nitrate and vasodilator. Current immediate-release tablets contain 5 mg, 10 mg, 20 mg, 30 mg, or 40 mg. They are indicated for prevention of angina pectoris due to coronary artery disease.
read more about isosorbide dinitrate ...Isosorbide dinitrate relaxes vascular smooth muscle and dilates veins and arteries. Venous dilation reduces blood return to the heart and lowers cardiac preload, while arterial dilation reduces vascular resistance. These effects reduce myocardial oxygen demand.
Immediate-release isosorbide dinitrate is used to prevent angina caused by coronary artery disease. Its onset is not rapid enough to stop an acute angina attack after symptoms begin. Safety and efficacy in pediatric patients are not established.
The usual starting dose is 5 mg to 20 mg two or three times daily. Maintenance dosing is 10 mg to 40 mg two or three times daily. A daily dose-free interval of at least 14 hours is advised to reduce nitrate tolerance.
Isosorbide dinitrate can cause severe low blood pressure, fainting, dizziness, headache, and worsening angina related to hypotension. Phosphodiesterase-5 inhibitors such as sildenafil, tadalafil, or vardenafil and the soluble guanylate cyclase stimulator riociguat are contraindicated due to severe hypotension risk. Methemoglobinemia has also been reported with organic nitrates.
It is used to prevent angina caused by coronary artery disease.
The usual starting dose is 5 mg to 20 mg two or three times daily.
A nitrate-free period helps reduce development of tolerance during chronic treatment.
No. The immediate-release oral tablets do not act rapidly enough to stop an attack after it begins.
Isosorbide: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682348.html. Date Accessed October 5, 2026.
Isosorbide. https://www.ncbi.nlm.nih.gov/books/NBK557839/. Date Accessed October 5, 2026.
Isosorbide Dinitrate Tablets Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b166eb5b-bad8-4663-9c05-1c43539dab2c. Date Accessed October 5, 2026.
Isosorbide Dinitrate Tablets Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?audience=professional&setid=6c4997e7-9ce6-46a6-a9c1-4bd3d76155eb. Date Accessed October 5, 2026.
Nitrates. https://www.ncbi.nlm.nih.gov/books/NBK545149/. Date Accessed October 5, 2026.