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Insulin lispro is a rapid-acting human insulin analog used to improve glycemic control in adults and children with diabetes mellitus. Current Humalog-based formulations include U-100 and U-200 strengths with route restrictions that differ by concentration.
read more about insulin lispro ...Insulin lispro increases glucose uptake in skeletal muscle and fat and decreases glucose production in the liver. It also reduces lipolysis and proteolysis and increases protein synthesis. Its rapid onset supports meal-time insulin treatment.
Insulin lispro is used in adults and pediatric patients with diabetes mellitus when rapid-acting insulin is part of the treatment regimen. U-100 can be given by subcutaneous injection, compatible insulin pumps, or intravenous infusion under medical supervision. U-200 is used only by subcutaneous injection.
Dosing is individualized according to metabolic needs, blood glucose results, meals, activity, and the rest of the diabetes regimen. U-100 and U-200 Humalog-based products are injected within 15 minutes before a meal or immediately after a meal. U-200 is not used in insulin pumps or by intravenous infusion.
Hypoglycemia can be life-threatening. Other concerns include hypokalemia, severe hypersensitivity, medication errors, lipodystrophy, localized cutaneous amyloidosis, and fluid retention or heart failure with thiazolidinediones. Pump interruption with U-100 can rapidly lead to hyperglycemia and ketoacidosis.
Insulin lispro is a rapid-acting human insulin analog.
It is injected within 15 minutes before a meal or immediately after a meal.
No. Current labeling directs against pump use with U-200 insulin lispro.
Yes. U-100 can be administered intravenously after dilution under medical supervision.
ADMELOG (Insulin Lispro) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0691def8-4a7b-4de3-866f-a280989f47f1. Date Accessed October 5, 2026.
HUMALOG (Insulin Lispro) Prescribing Information. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c8ecbd7a-0e22-4fc7-a503-faa58c1b6f3f. Date Accessed October 5, 2026.
Insulin Lispro. https://www.ncbi.nlm.nih.gov/books/NBK507840/. Date Accessed October 5, 2026.
Insulin Lispro Injection: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a697021.html. Date Accessed October 5, 2026.
LYUMJEV (Insulin Lispro-aabc) Prescribing Information. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c5a056e2-b568-4ca6-9ed8-79c010942d00. Date Accessed October 5, 2026.