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What Is INFeD?

INFeD is a prescription iron dextran injection containing 50 mg of elemental iron per mL. It is indicated for adults and children age 4 months and older with documented iron deficiency who cannot tolerate oral iron or have an unsatisfactory response to oral iron.

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What Is INFeD?

INFeD is a prescription iron dextran injection containing 50 mg of elemental iron per mL. It is indicated for adults and children age 4 months and older with documented iron deficiency who cannot tolerate oral iron or have an unsatisfactory response to oral iron.

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How Does INFeD Restore Iron?

Iron dextran enters normal iron-handling pathways after administration. Released iron binds to transport and storage proteins and becomes available for incorporation into hemoglobin and replenishment of iron stores.

Who Is Treated With INFeD?

INFeD is used in adults and pediatric patients age 4 months and older after laboratory testing confirms iron deficiency and oral iron is unsuitable or has produced an unsatisfactory response. Hemoglobin, hematocrit, serum iron, total iron-binding capacity, and transferrin saturation are assessed during treatment.

How Is INFeD Administered?

The total replacement amount is calculated from body size, hemoglobin deficit, and iron requirements. A 0.5 mL test dose is given before the first therapeutic intravenous or intramuscular dose, followed by observation for at least one hour before treatment continues. For most patients, the daily amount does not exceed 2 mL or 100 mg of elemental iron.

What Serious Risks Are Linked to INFeD?

INFeD carries a boxed warning for anaphylactic-type reactions, including fatal reactions. Resuscitation equipment and trained personnel are present during administration. A tolerated test dose does not eliminate the risk of a later fatal reaction. Other concerns include delayed reactions, low blood pressure, iron overload, and reactions at the injection site.

Frequently Asked Questions About INFeD

What condition does INFeD treat?

INFeD treats documented iron deficiency when oral iron cannot be tolerated or has produced an unsatisfactory response.

How much elemental iron does INFeD contain?

INFeD contains 50 mg of elemental iron per mL.

Is a test dose required before the first therapeutic dose?

Yes. Current labeling calls for a 0.5 mL test dose before the first therapeutic intravenous or intramuscular dose.

Does INFeD have a boxed warning?

Yes. The boxed warning concerns serious and fatal anaphylactic-type reactions.

References

DailyMed - INFED - iron dextran injection. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=99bf34be-cb8a-46d1-9637-5544dc2da287. Date Accessed October 2, 2026.

Iron Dextran Injection - MedlinePlus Drug Information. https://www.medlineplus.gov/druginfo/meds/a614033.html. Date Accessed October 2, 2026.

Iron Dextran - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Iron-Dextran. Date Accessed October 2, 2026.

Iron Dextran - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK557747/. Date Accessed October 2, 2026.

Parenteral Iron Dextran Therapy - A Review. https://pubmed.ncbi.nlm.nih.gov/7647482/. Date Accessed October 2, 2026.