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Imitrex is a prescription triptan containing sumatriptan. Current Imitrex tablets contain 25 mg, 50 mg, or 100 mg of sumatriptan and are indicated for acute treatment of migraine with or without aura in adults. The tablets are not indicated for migraine prevention or treatment of cluster headache.
read more about imitrex ...Sumatriptan binds to 5-HT1B and 5-HT1D serotonin receptors. Its migraine activity is associated with constriction of cranial blood vessels and inhibition of proinflammatory neuropeptide release from sensory nerves in the trigeminal system.
Imitrex tablets are used in adults with a clear diagnosis of migraine with or without aura. Current tablet labeling does not establish safety and efficacy in pediatric patients and does not include cluster headache treatment.
A single oral dose can be 25 mg, 50 mg, or 100 mg. If the migraine returns after an initial response, a second dose can be taken at least two hours after the first. The maximum oral dose is 200 mg in 24 hours.
Serious risks include heart attack, coronary artery vasospasm, dangerous heart rhythm disturbances, stroke, other vascular events, serotonin syndrome, seizures, medication overuse headache, and severe increases in blood pressure. Contraindications include ischemic coronary disease, prior stroke or transient ischemic attack, peripheral vascular disease, uncontrolled hypertension, severe liver impairment, and selected interacting migraine or monoamine oxidase inhibitor medicines.
Imitrex tablets treat acute migraine with or without aura in adults.
Current Imitrex tablets contain 25 mg, 50 mg, or 100 mg of sumatriptan.
A second dose can be taken at least two hours after the first when the migraine returns after an initial response.
The maximum tablet dose is 200 mg in 24 hours.
DailyMed - IMITREX - sumatriptan tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=584abe73-8290-4484-ff8e-5890831c095e. Date Accessed October 2, 2026.
IMITREX Prescribing Information - U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/020080s055lbl020132s031lbl.pdf. Date Accessed October 2, 2026.
Sumatriptan - MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a601116.html. Date Accessed October 2, 2026.
Sumatriptan - PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Sumatriptan. Date Accessed October 2, 2026.
Sumatriptan - StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK470206/. Date Accessed October 2, 2026.