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Hydrocodone and ibuprofen is a prescription combination analgesic for short-term acute pain severe enough to require an opioid when alternative treatments are inadequate. A current active tablet contains 7.5 mg of hydrocodone bitartrate and 200 mg of ibuprofen. The product is a Schedule II controlled substance.
read more about hydrocodone and ibuprofen ...Hydrocodone activates mu-opioid receptors in the central nervous system and changes pain perception. Ibuprofen is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase activity and reduces prostaglandin synthesis. The combination targets pain through opioid and anti-inflammatory mechanisms.
The combination is reserved for short-term treatment of acute pain severe enough to require an opioid when alternatives are inadequate. Current labeling describes treatment as typically less than 10 days. It is not intended for long-term conditions such as osteoarthritis or rheumatoid arthritis.
The current 7.5 mg/200 mg tablet is taken as one tablet every four to six hours as needed for pain. The dose does not exceed five tablets in 24 hours. Treatment uses the lowest dose needed for the shortest appropriate period.
The boxed warning covers opioid-related risks and serious cardiovascular and gastrointestinal events from ibuprofen. Risks include addiction, respiratory depression, accidental ingestion, neonatal opioid withdrawal, dangerous central nervous system depressant interactions, heart attack, stroke, gastrointestinal bleeding, ulceration, and perforation. Use during coronary artery bypass graft surgery is contraindicated.
It is used for short-term acute pain severe enough to require an opioid when alternative treatments are inadequate.
The tablet contains 7.5 mg of hydrocodone bitartrate and 200 mg of ibuprofen.
One tablet is taken every four to six hours as needed for pain.
The labeled maximum is five tablets in 24 hours.
DailyMed - HYDROCODONE BITARTRATE AND IBUPROFEN tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=470df63a-5c0f-42df-9023-a330a901153e. Date Accessed October 1, 2026.
FDALabel - Hydrocodone Bitartrate and Ibuprofen. U.S. Food and Drug Administration. https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/431386. Date Accessed October 1, 2026.
Hydrocodone Bitartrate; Ibuprofen. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/11445193. Date Accessed October 1, 2026.
Hydrocodone Combination Products. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601006.html. Date Accessed October 1, 2026.
Hydrocodone. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK537288/. Date Accessed October 1, 2026.