Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Hydrochlorothiazide and valsartan is a prescription fixed-dose combination used to treat hypertension. Valsartan is an angiotensin II receptor blocker and hydrochlorothiazide is a thiazide diuretic. Current tablet strengths include 80 mg/12.5 mg, 160 mg/12.5 mg, 160 mg/25 mg, 320 mg/12.5 mg, and 320 mg/25 mg.
read more about hydrochlorothiazide and valsartan ...Valsartan blocks angiotensin II at the AT1 receptor and reduces vasoconstriction and aldosterone-related effects. Hydrochlorothiazide reduces sodium and chloride reabsorption in the distal renal tubule and increases urinary sodium and water excretion. Their actions lower blood pressure through different pathways.
The combination treats adults with hypertension whose blood pressure is not adequately controlled with either component alone. It can also be used as initial therapy when treatment with more than one antihypertensive medicine is appropriate. It is not recommended as initial therapy in patients with intravascular volume depletion.
The usual starting dose is 160 mg valsartan with 12.5 mg hydrochlorothiazide once daily. The dose can increase after one to two weeks to a maximum of 320 mg/25 mg once daily when further blood pressure reduction is needed. Maximum antihypertensive effects develop within two to four weeks after a dose change.
The combination carries a boxed warning for fetal toxicity and is stopped when pregnancy is detected. Other concerns include low blood pressure, impaired kidney function, potassium and other electrolyte abnormalities, acute angle-closure glaucoma, high uric acid, and hypersensitivity. Aliskiren use is contraindicated in patients with diabetes.
The combination treats hypertension in adults.
The usual starting dose is 160 mg valsartan with 12.5 mg hydrochlorothiazide once daily.
The maximum labeled dose is 320 mg valsartan with 25 mg hydrochlorothiazide once daily.
Yes. The boxed warning concerns fetal toxicity.
Angiotensin Receptor Blockers and HCTZ Combination Drugs. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK606100/. Date Accessed October 1, 2026.
DailyMed - DIOVAN HCT (valsartan and hydrochlorothiazide) tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d76a0419-05ee-437e-884c-65807aea9569. Date Accessed October 1, 2026.
DailyMed - VALSARTAN AND HYDROCHLOROTHIAZIDE tablet, film coated. https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ba10848-9a4c-1a28-e063-6394a90ab047. Date Accessed October 1, 2026.
Hydrochlorothiazide; Valsartan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/9810581. Date Accessed October 1, 2026.
Valsartan and Hydrochlorothiazide. MedlinePlus. https://medlineplus.gov/druginfo/meds/a611032.html. Date Accessed October 1, 2026.