Provide a valuable resource to your clients or customers by linking to this resource page. Just place the following link on your website.
Hydrochlorothiazide and losartan is a prescription fixed-dose combination containing an angiotensin II receptor blocker and a thiazide diuretic. It treats hypertension and is also indicated to reduce stroke risk in selected patients with hypertension and left ventricular hypertrophy.
read more about hydrochlorothiazide and losartan ...Losartan blocks angiotensin II at the AT1 receptor and reduces vasoconstriction and aldosterone-related effects. Hydrochlorothiazide increases urinary sodium and water excretion through action in the distal renal tubule. The two components lower blood pressure through different mechanisms.
The combination is used in adults with hypertension, including selected patients whose blood pressure is not controlled with either component alone. It is also used to reduce stroke risk in patients with hypertension and left ventricular hypertrophy, although the labeled stroke benefit was not demonstrated in Black patients.
The usual starting dose for hypertension is 50 mg losartan with 12.5 mg hydrochlorothiazide once daily. The dose can increase after about three weeks to a maximum of 100 mg/25 mg once daily. Current strengths also include 100 mg/12.5 mg.
The combination carries a boxed warning for fetal toxicity. Other concerns include low blood pressure, kidney impairment, electrolyte abnormalities, acute angle-closure glaucoma, high uric acid, hypersensitivity, and nonmelanoma skin cancer linked to hydrochlorothiazide exposure. Aliskiren is contraindicated in patients with diabetes.
It treats hypertension and reduces stroke risk in selected patients with hypertension and left ventricular hypertrophy.
The usual starting dose is 50 mg losartan with 12.5 mg hydrochlorothiazide once daily.
The maximum labeled dose for hypertension is 100 mg losartan with 25 mg hydrochlorothiazide once daily.
Yes. The boxed warning concerns fetal toxicity.
Angiotensin Receptor Blockers and HCTZ Combination Drugs. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK606100/. Date Accessed October 1, 2026.
DailyMed - HYZAAR (losartan potassium and hydrochlorothiazide) tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4116ccde-2e23-45f4-b12f-6337df877744. Date Accessed October 1, 2026.
DailyMed - LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE tablet, film coated. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1d6712a3-bfb3-4081-b8f6-6057eb4baa27. Date Accessed October 1, 2026.
Hydrochlorothiazide Mixture With Losartan. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Losartan-potassium-and-hydrochlorothiazide. Date Accessed October 1, 2026.
Losartan. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a695008.html. Date Accessed October 1, 2026.