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Hydralazine hydrochloride is a prescription antihypertensive medicine used alone or with other medicines for hypertension. Oral tablets are available in several strengths, including 10 mg, 25 mg, 50 mg, and 100 mg.
read more about hydralazine ...The precise mechanism is not fully defined. Hydralazine directly relaxes vascular smooth muscle and acts mainly on arterioles, which lowers peripheral vascular resistance and arterial blood pressure. Reflex increases in heart rate, stroke volume, cardiac output, and renin activity can occur.
Oral hydralazine labeling covers hypertension as monotherapy or adjunctive therapy. Coronary artery disease and mitral valvular rheumatic heart disease are contraindications. Patients receiving long-term therapy undergo clinical and laboratory assessment for adverse effects associated with treatment.
Current oral labeling starts with 10 mg four times daily for the first two to four days, then 25 mg four times daily for the remainder of the first week. From the second week, the dose can increase to 50 mg four times daily. Maintenance dosing is adjusted to the lowest dose that controls blood pressure.
Hydralazine can cause a lupus-like syndrome that can include glomerulonephritis. Myocardial stimulation can trigger angina, ischemic electrocardiogram changes, or myocardial infarction in susceptible patients. Other reported concerns include peripheral neuritis and blood-cell abnormalities. Higher daily doses are associated with greater toxicity risk.
Oral hydralazine is indicated for hypertension, either alone or with other antihypertensive medicines.
Hydralazine directly relaxes vascular smooth muscle and reduces peripheral vascular resistance.
Current labeling starts with 10 mg four times daily for the first two to four days.
Yes. A lupus-like syndrome, including glomerulonephritis, has been reported during treatment.
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Hydralazine. LiverTox. https://www.ncbi.nlm.nih.gov/books/NBK548580/. Date Accessed October 1, 2026.
Hydralazine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682246.html. Date Accessed October 1, 2026.
Hydralazine. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Hydralazine. Date Accessed October 1, 2026.
Hydralazine. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK470296/. Date Accessed October 1, 2026.