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Guanfacine is a prescription medicine that acts on alpha-2A adrenergic receptors. Immediate-release tablets are used to treat high blood pressure. Extended-release tablets are used to treat attention deficit hyperactivity disorder, or ADHD.
read more about guanfacine ...Guanfacine reduces certain nerve signals from the brain. For high blood pressure, this slows the heart rate and relaxes blood vessels. Its action in areas involved in attention and impulse control helps manage ADHD symptoms.
Take guanfacine at about the same time each day as prescribed. Swallow extended-release tablets whole rather than crushing, chewing, or breaking them. Immediate-release and extended-release tablets have different dosing instructions and should not be substituted dose for dose.
Sleepiness, dizziness, dry mouth, and low blood pressure can occur. Rise slowly from sitting or lying down if you feel lightheaded. Tell your prescriber about fainting or side effects that interfere with daily activities.
Do not stop guanfacine abruptly without speaking to your prescriber. Blood pressure can rise after sudden discontinuation. A clinician can provide a gradual dose reduction when treatment needs to end.
Extended-release guanfacine is used to manage ADHD symptoms. The immediate-release form has a different labeled use.
Yes. See how it affects you before driving or doing tasks that require alertness.
No. Swallow it whole so the medicine is released as intended.
Do not stop without medical guidance. Sudden discontinuation can raise blood pressure.
Guanfacine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a601059.html. Date Accessed October 6, 2026.
Guanfacine (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/guanfacine-oral-route/description/drg-20064131. Date Accessed October 6, 2026.
GUANFACINE HYDROCHLORIDE- guanfacine tablet. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a80dfdc4-b9a7-4f8e-af67-dea30bc063ac. Date Accessed October 6, 2026.
Guanfacine Immediate Release Oral Tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/18184-guanfacine-tablets. Date Accessed October 6, 2026.
GUANFACINE tablet, extended release. DailyMed (National Library of Medicine). https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ab2e3597-14fc-4614-ae87-0d1d18188a68. Date Accessed October 6, 2026.