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What Is Goserelin?

Goserelin is a gonadotropin-releasing hormone agonist given as an implant under the skin. It is used for certain prostate and breast cancers and for conditions such as endometriosis. Its uses and treatment duration depend on the diagnosis.

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What Is Goserelin?

Goserelin is a gonadotropin-releasing hormone agonist given as an implant under the skin. It is used for certain prostate and breast cancers and for conditions such as endometriosis. Its uses and treatment duration depend on the diagnosis.

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How Goserelin Works

Goserelin changes the signals that control sex hormone production. After an initial rise in hormone levels, ongoing treatment lowers testosterone or estrogen levels. This effect can help manage conditions influenced by those hormones.

How the Implant Is Given

A clinician places the implant under the skin of the abdomen. Depending on the product strength and treatment plan, it may be given every four or 12 weeks. Keep scheduled appointments so treatment stays on course.

Possible Side Effects

Hot flashes, sweating, headache, and changes in sexual function can occur. The injection site may become sore or irritated. Goserelin can reduce bone density, and symptoms related to a cancer may temporarily worsen when treatment begins.

Pregnancy and Monitoring

Goserelin can harm a developing fetus. Discuss pregnancy testing and contraception with your care team when applicable. Your clinician may monitor symptoms, bone health, and your response to treatment.

Frequently Asked Questions About Goserelin

Is goserelin a pill?

No. A clinician places it as an implant beneath the skin of the abdomen.

How frequently is goserelin given?

Implant schedules can be every four or 12 weeks, depending on the strength and indication. Follow the schedule set by your clinician.

Can symptoms worsen when goserelin is started?

Hormone levels can rise briefly at the start of treatment. Tell your care team about new or worsening symptoms.

Does goserelin affect bones?

It can reduce bone density and raise the risk of fractures. Your clinician can discuss monitoring and steps appropriate to your treatment.

References

Goserelin (subcutaneous route) - Side effects & uses. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/goserelin-subcutaneous-route/description/drg-20067310. Date Accessed October 6, 2026.

Goserelin Acetate. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/goserelinacetate. Date Accessed October 6, 2026.

Goserelin Implant. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a601002.html. Date Accessed October 6, 2026.

Goserelin injection. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/18149-goserelin-injection. Date Accessed October 6, 2026.

ZOLADEX (goserelin acetate) 3.6 mg implant: Prescribing Information. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?audience=consumer&setid=a906a5bd-d2ec-4e35-8962-c0c86c637630. Date Accessed October 6, 2026.