What Is Galcanezumab?
Galcanezumab is a prescription monoclonal antibody sold under the brand name Emgality. It targets calcitonin gene-related peptide, or CGRP. It is given by injection under the skin.
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What Is Galcanezumab Used For?
Galcanezumab is used to prevent migraine in adults. It is also used to treat episodic cluster headache in adults. The doses and injection devices differ between these uses.
How Does Galcanezumab Work?
Galcanezumab binds to CGRP, a substance involved in migraine and cluster headache pathways. This keeps CGRP from attaching to its receptor. It is used on a treatment schedule rather than to provide immediate relief during an attack.
How Is Galcanezumab Given?
Galcanezumab is injected under the skin, generally on a monthly schedule. Migraine prevention begins with a loading dose, while episodic cluster headache uses a different dose during a cluster period. Follow the instructions for the specific prescribed device and condition.
What Are Galcanezumab Side Effects and Precautions?
Pain, redness, or itching at the injection site can occur. Serious allergic reactions can happen, sometimes after the injection. Severe constipation, new or worsening high blood pressure, and symptoms of Raynaud phenomenon also need medical assessment.
Frequently Asked Questions About Galcanezumab
Can galcanezumab stop a migraine already in progress?
It is prescribed to prevent migraine, not for immediate attack relief. Follow the separate acute treatment plan given by your clinician.
Is the dose the same for migraine and cluster headache?
No. The two uses have different dosing instructions and injection devices.
How frequently is galcanezumab given?
It is generally given monthly. For episodic cluster headache, dosing is tied to the cluster period.
What side effects should I report?
Seek care for signs of a serious allergic reaction. Tell the prescriber about severe constipation, higher blood pressure, or fingers and toes that become painful or change color in the cold.
References
EMGALITY (galcanezumab-gnlm) injection: Prescribing Information. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=33a147be-233a-40e8-a55e-e40936e28db0. Date Accessed October 6, 2026.
Galcanezumab injection. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/21320-galcanezumab-injection. Date Accessed October 6, 2026.
Galcanezumab-gnlm (subcutaneous route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/galcanezumab-gnlm-subcutaneous-route/description/drg-20444084. Date Accessed October 6, 2026.
Galcanezumab-gnlm Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a618063.html. Date Accessed October 6, 2026.
Migraine - Diagnosis and treatment. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/migraine-headache/diagnosis-treatment/drc-20360207. Date Accessed October 6, 2026.