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What Is Fycompa?

Fycompa is the brand name for perampanel, a prescription antiseizure medicine. It is taken by mouth as a tablet or liquid suspension. It is used for specific types of seizures in people with epilepsy.

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What Is Fycompa?

Fycompa is the brand name for perampanel, a prescription antiseizure medicine. It is taken by mouth as a tablet or liquid suspension. It is used for specific types of seizures in people with epilepsy.

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What Is Fycompa Used For?

Fycompa treats focal-onset seizures in people aged 4 years and older. It can also be added to other medicines for primary generalized tonic-clonic seizures in people aged 12 years and older. The prescriber selects the dose according to seizure type, age, and response.

How Does Fycompa Work?

Perampanel blocks AMPA receptors involved in excitatory signaling between nerve cells. This reduces electrical activity that can contribute to seizures. It helps control seizures but does not cure epilepsy.

How Is Fycompa Taken?

Fycompa is usually taken once daily at bedtime. A clinician generally starts with a low dose and raises it gradually if needed. Do not stop it suddenly without a plan from the prescriber.

What Are Fycompa Side Effects and Precautions?

Dizziness, sleepiness, and balance problems can occur and may increase the risk of falls. Fycompa carries a boxed warning for serious mood and behavior changes, including aggression and hostility. Contact the prescriber immediately about unusual anger, threatening behavior, or major changes in mood or personality.

Frequently Asked Questions About Fycompa

Can Fycompa cause mood changes?

Yes. Serious irritability, aggression, and other behavioral changes have been reported, even in people without a prior psychiatric condition.

Is Fycompa taken with other seizure medicines?

It can be used alone or with other medicines for focal-onset seizures. For primary generalized tonic-clonic seizures, it is used as an added treatment.

Why is Fycompa usually taken at bedtime?

It can cause dizziness and sleepiness. Follow the dosing time given by the prescriber.

Can I stop taking Fycompa suddenly?

Speak with the prescriber first. Stopping an antiseizure medicine abruptly can increase seizure risk.

References

FYCOMPA (perampanel) tablets and oral suspension: Prescribing Information. DailyMed (National Library of Medicine). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec812ea3-de3a-4271-957c-db8f692d1ae3. Date Accessed October 6, 2026.

FYCOMPA (perampanel): Prescribing Information. Eisai. https://www.fycompa.com/hcp/media/media/Files/FycompaHCP/Fycompa_Prescribing_Information.pdf. Date Accessed October 6, 2026.

Perampanel. MedlinePlus. https://medlineplus.gov/druginfo/meds/a614006.html. Date Accessed October 6, 2026.

Perampanel (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/perampanel-oral-route/description/drg-20075877. Date Accessed October 6, 2026.

Perampanel Tablets. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/20930-perampanel-tablets. Date Accessed October 6, 2026.