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What Are Fluticasone and Salmeterol?

Fluticasone and salmeterol are combined in a maintenance inhaler. Fluticasone is a corticosteroid that reduces airway inflammation. Salmeterol is a long-acting bronchodilator that helps keep airways open.

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What Are Fluticasone and Salmeterol?

Fluticasone and salmeterol are combined in a maintenance inhaler. Fluticasone is a corticosteroid that reduces airway inflammation. Salmeterol is a long-acting bronchodilator that helps keep airways open.

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What Are Fluticasone and Salmeterol Used For?

The combination is used for long-term asthma control in eligible patients. Certain products are also used to manage chronic obstructive pulmonary disease, or COPD. Approved uses and ages vary by inhaler product.

How Do Fluticasone and Salmeterol Work?

Fluticasone reduces swelling and irritation in the airways. Salmeterol relaxes muscles around the airways for prolonged bronchodilation. Together, they help control ongoing breathing symptoms when used as prescribed.

How Are Fluticasone and Salmeterol Used?

The medicine is inhaled through the mouth, usually twice daily. The inhaler steps differ between aerosol and dry-powder products, so follow the instructions supplied with yours. Rinse the mouth with water and spit it out after each dose.

What Are Fluticasone and Salmeterol Side Effects and Precautions?

Throat irritation, hoarseness, headache, and oral thrush can occur. Salmeterol can cause a fast heartbeat or tremor in some people. This combination does not treat a sudden asthma or COPD attack, so keep the prescribed rescue treatment available.

Frequently Asked Questions About Fluticasone and Salmeterol

Can this inhaler stop a sudden asthma attack?

No. Use the prescribed rescue inhaler for sudden symptoms.

Why does the inhaler contain two medicines?

Fluticasone reduces airway inflammation, while salmeterol helps keep the airways open. The combination supports ongoing symptom control.

Should I use it when I feel well?

Continue using it on the prescribed schedule unless your clinician changes the plan. Stopping can allow symptoms to return.

Why should I rinse my mouth after a dose?

Rinsing and spitting lowers the risk of oral thrush. It also helps clear medicine left in the mouth.

References

ADVAIR HFA- fluticasone propionate and salmeterol xinafoate aerosol, metered. DailyMed (National Library of Medicine). https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dfaca6f9-3277-47b2-319d-1377917cb54c. Date Accessed October 6, 2026.

Fluticasone and salmeterol (inhalation route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fluticasone-and-salmeterol-inhalation-route/description/drg-20063110. Date Accessed October 6, 2026.

Fluticasone and Salmeterol Oral Inhalation. MedlinePlus. https://medlineplus.gov/druginfo/meds/a699063.html. Date Accessed October 6, 2026.

FLUTICASONE PROPIONATE AND SALMETEROL powder. DailyMed (National Library of Medicine). https://www.dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1349a04c-2024-42b9-b81d-a7d995716ade. Date Accessed October 6, 2026.

Fluticasone; Salmeterol Powder Inhaler. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19911-fluticasone-salmeterol-powder-inhaler. Date Accessed October 6, 2026.