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What Is Fluphenazine?

Fluphenazine is a prescription antipsychotic medicine. It is used to treat schizophrenia and related psychotic symptoms. It is available in oral forms and as a long-acting injection called fluphenazine decanoate.

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What Is Fluphenazine?

Fluphenazine is a prescription antipsychotic medicine. It is used to treat schizophrenia and related psychotic symptoms. It is available in oral forms and as a long-acting injection called fluphenazine decanoate.

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What Is Fluphenazine Used For?

Fluphenazine helps manage symptoms such as hallucinations and delusions. A long-acting injection can be used when ongoing injectable treatment is appropriate. The choice of form depends on the treatment plan and response to the medicine.

How Does Fluphenazine Work?

Fluphenazine changes the activity of dopamine signaling in the brain. This can reduce psychotic symptoms. Its effect on dopamine can also cause movement-related side effects.

How Is Fluphenazine Taken?

Oral fluphenazine is taken on a regular schedule prescribed by a clinician. Fluphenazine decanoate is injected by a healthcare professional at scheduled intervals. The oral and injectable forms have different doses and should not be substituted without medical guidance.

What Are Fluphenazine Side Effects and Precautions?

Drowsiness, dizziness, dry mouth, and movement problems can occur. Report new involuntary movements, muscle stiffness, or severe restlessness to a clinician. Antipsychotics such as fluphenazine carry an increased risk of death in older adults with dementia-related psychosis and are not approved for that use.

Frequently Asked Questions About Fluphenazine

Is fluphenazine available as an injection?

Yes. Fluphenazine decanoate is a long-acting injection given on a schedule set by a clinician.

Can fluphenazine cause involuntary movements?

Yes. Report movements of the face, mouth, tongue, or other body parts promptly.

Can I stop fluphenazine when symptoms improve?

Do not stop without speaking with the prescriber. Continuing treatment can help prevent symptoms from returning.

Does fluphenazine cause drowsiness?

It can. Avoid driving or operating machinery until you know how it affects you.

References

Fluphenazine. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a682172.html. Date Accessed October 6, 2026.

Fluphenazine. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK459194/. Date Accessed October 6, 2026.

Fluphenazine (Prolixin): Uses & Side Effects. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/20254-fluphenazine-tablets. Date Accessed October 6, 2026.

Phenothiazine. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK556113/. Date Accessed October 6, 2026.

Tardive dyskinesia. MedlinePlus. https://medlineplus.gov/ency/article/000685.htm. Date Accessed October 6, 2026.