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Fluorouracil, also called 5-FU, is a medicine that interferes with the growth of abnormal cells. Topical forms are applied to certain skin lesions. An injectable form is used as chemotherapy for some cancers.
read more about fluorouracil ...Fluorouracil cream or solution treats actinic keratoses and, in selected cases, superficial basal cell carcinoma. Injectable fluorouracil is used in treatment plans for cancers such as colorectal, breast, stomach, and pancreatic cancer. The skin and injectable forms have different dosing and safety instructions.
Fluorouracil is an antimetabolite that disrupts processes cells need to make new DNA. Cells that divide rapidly are especially vulnerable to its effects. This includes the abnormal cells targeted by treatment, as well as some healthy cells.
Topical fluorouracil is applied to the prescribed skin area for a course that can last several weeks. Injectable fluorouracil is given into a vein by a healthcare professional as part of a cancer treatment schedule. Follow the instructions for the specific form prescribed.
Topical treatment commonly causes redness, scaling, and soreness before the skin heals. Injectable treatment can cause serious effects, including mouth sores, diarrhea, and low blood cell counts. A deficiency of the enzyme DPD raises the risk of severe toxicity, particularly with injectable fluorouracil.
No. The cream treats selected skin lesions, while the injection is used in certain cancer treatment plans.
Redness and irritation are common as treated skin reacts. Contact the prescriber if the reaction is severe or you are unsure whether to continue.
No. Keep it away from the eyes, eyelids, nose, and mouth, and wash your hands after applying it.
People with low DPD activity can have a higher risk of severe reactions to fluorouracil chemotherapy. The cancer team can assess this risk before treatment.
Fluorouracil (intravenous route, injection route) - Side effects & uses. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fluorouracil-intravenous-route-injection-route/description/drg-20063861. Date Accessed October 6, 2026.
Fluorouracil (topical route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fluorouracil-topical-route/description/drg-20063877. Date Accessed October 6, 2026.
Fluorouracil Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682708.html. Date Accessed October 6, 2026.
Fluorouracil Injection. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/fluorouracil. Date Accessed October 6, 2026.
Fluorouracil Topical. MedlinePlus. https://medlineplus.gov/druginfo/meds/a605010.html. Date Accessed October 6, 2026.