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Fludrocortisone is a prescription corticosteroid with strong mineralocorticoid activity. It helps the body retain sodium and water and release potassium. It is used when the body does not make enough of certain adrenal hormones.
read more about fludrocortisone ...Fludrocortisone is used to replace mineralocorticoid activity in conditions such as Addison disease and salt-losing congenital adrenal hyperplasia. It helps maintain blood volume and blood pressure. People with adrenal insufficiency may also need a separate glucocorticoid medicine.
Fludrocortisone acts on the kidneys to increase sodium retention and potassium excretion. Water follows the retained sodium, helping support blood volume. The same effects can raise blood pressure or cause fluid retention if the dose is too high.
Fludrocortisone is taken by mouth on the schedule prescribed by a clinician. The dose may be adjusted using symptoms, blood pressure, and blood test results. Do not change or stop treatment without medical guidance.
Possible effects include swelling, higher blood pressure, weight gain, and low blood potassium. Heart or kidney conditions may require closer monitoring. Report marked swelling, muscle weakness, or a substantial change in blood pressure.
No. Fludrocortisone mainly replaces mineralocorticoid activity, while hydrocortisone mainly replaces glucocorticoid activity.
Clinicians may check blood pressure, body weight, sodium, and potassium. These findings help guide the dose.
Yes. Its sodium and water retention effects can lead to swelling, especially if the dose is too high.
Do not stop it without speaking with the prescribing clinician. People who need adrenal hormone replacement require a plan to maintain that treatment.
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Fludrocortisone. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK564331/. Date Accessed October 6, 2026.
Fludrocortisone (Florinef): Uses & Side Effects. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/19623-fludrocortisone-tablets. Date Accessed October 6, 2026.
Fludrocortisone (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fludrocortisone-oral-route/description/drg-20063868. Date Accessed October 6, 2026.
Fludrocortisone Acetate. MedlinePlus. https://medlineplus.gov/druginfo/meds/a682549.html. Date Accessed October 6, 2026.