What Is Fluconazole?
Fluconazole is a prescription antifungal medicine. It treats certain infections caused by fungi, including Candida and Cryptococcus species. It is available in oral and intravenous forms.
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What Is Fluconazole Used For?
Fluconazole can treat vaginal yeast infections and Candida infections of the mouth or esophagus. It is also used for some serious fungal infections, including cryptococcal meningitis. The dose and length of treatment depend on the infection and the person receiving treatment.
How Does Fluconazole Work?
Fluconazole interferes with the production of ergosterol, a component of fungal cell membranes. Without enough ergosterol, susceptible fungi cannot grow normally. It does not treat bacterial infections.
How Is Fluconazole Taken?
Fluconazole may be taken as a tablet or oral suspension, or given intravenously. An uncomplicated vaginal yeast infection may require one oral dose, while other infections need longer treatment. Kidney function and other medicines can affect the prescribed regimen.
What Are Fluconazole Side Effects and Precautions?
Possible side effects include nausea, headache, and abdominal discomfort. Rare but serious problems include liver injury and changes in heart rhythm. Tell a clinician about pregnancy, liver or kidney disease, and all other medicines before taking it.
Frequently Asked Questions About Fluconazole
Is one dose of fluconazole enough?
One dose is a common regimen for uncomplicated vaginal yeast infections. Other infections can require repeated doses or weeks of treatment.
Does fluconazole treat bacterial infections?
No. Fluconazole is an antifungal medicine and does not replace an antibiotic when bacteria are the cause.
Can fluconazole interact with other medicines?
Yes. It can change the effects of several medicines, so a clinician or pharmacist should review your medication list.
Can fluconazole be taken during pregnancy?
Pregnancy can change the choice of antifungal treatment. Ask a clinician before taking oral fluconazole if you are pregnant or could be pregnant.
References
Fluconazole. MedlinePlus. https://www.medlineplus.gov/druginfo/meds/a690002.html. Date Accessed October 6, 2026.
Fluconazole. StatPearls (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK537158/. Date Accessed October 6, 2026.
Fluconazole (Diflucan?). MotherToBaby (NCBI Bookshelf). https://www.ncbi.nlm.nih.gov/books/NBK582709/?report=printable. Date Accessed October 6, 2026.
Fluconazole (oral route) - Side effects & dosage. Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/description/drg-20071428. Date Accessed October 6, 2026.
Fluconazole Injection. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601143.html. Date Accessed October 6, 2026.